Sonodynamically induced antitumor effect of Photofrin II on colon 26 carcinoma

The sonodynamically induced antitumor effect of Photofrin II (PF), was evaluated in mice bearing colon 26 carcinoma. In order to find the optimum timing for ultrasonic exposure after the administration of PF, the PF concentrations in the plasma, skin, muscle, and tumor were measured. The antitumor e...

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Bibliographic Details
Published in:Journal of cancer research and clinical oncology 2000-10, Vol.126 (10), p.601-606
Main Authors: YUMITA, Nagahiko, NISHIGAKI, Ryuichiro, UMEMURA, Shin-Ichiro
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents - pharmacokinetics
Antineoplastic Agents - pharmacology
Biological and medical sciences
Colonic Neoplasms - drug therapy
Colonic Neoplasms - metabolism
Dihematoporphyrin Ether - pharmacokinetics
Dihematoporphyrin Ether - pharmacology
Disease Models, Animal
Male
Medical sciences
Mice
Mice, Inbred BALB C
Other treatments
Time Factors
Treatment. General aspects
Tumors
Ultrasonic Therapy
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Summary:The sonodynamically induced antitumor effect of Photofrin II (PF), was evaluated in mice bearing colon 26 carcinoma. In order to find the optimum timing for ultrasonic exposure after the administration of PF, the PF concentrations in the plasma, skin, muscle, and tumor were measured. The antitumor effect was estimated by measuring the tumor size. Since the highest concentration of PF in the tumor was observed 24 h after administration, an ultrasonic exposure timing of 24 h after the intravenous administration of PF was chosen. When used alone, ultrasound showed a slight antitumor effect, which became increasingly significant as the dose of PF was increased, while use of PF alone showed no significant effect. From these results, it is concluded that PF significantly sensitizes solid tumors to ultrasound, demonstrating a synergistic antitumor effect.
ISSN:0171-5216
1432-1335
DOI:10.1007/pl00008471