The genetic basis for cytopathogenicity of pestiviruses

Two biotypes of pestiviruses, cytopathogenic (cp) and noncp viruses, can be distinguished by their effects on tissue culture cells. Identification of cp bovine viral diarrhea virus (BVDV) has been frequently reported since antigenically closely related noncp and cp BVDV can be isolated from cattle w...

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Bibliographic Details
Published in:Veterinary microbiology 2000-11, Vol.77 (1), p.117-128
Main Authors: Kümmerer, Beate M, Tautz, Norbert, Becher, Paul, Thiel, Heinz-Jürgen, Meyers, Gregor
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Border disease virus
Bovine viral diarrhea virus
Bovine Virus Diarrhea-Mucosal Disease - genetics
Bovine Virus Diarrhea-Mucosal Disease - virology
Cattle
Classical Swine Fever - genetics
Classical Swine Fever - virology
Classical swine fever virus
Classical Swine Fever Virus - genetics
Classical Swine Fever Virus - pathogenicity
Cytopathogenic Effect, Viral
Cytopathogenic virus
Diarrhea Viruses, Bovine Viral - genetics
Diarrhea Viruses, Bovine Viral - pathogenicity
Fundamental and applied biological sciences. Psychology
Genetics
Genome, Viral
Microbiology
Mucosal disease
NS2 gene
Pestivirus - genetics
Pestivirus - pathogenicity
Swine
Viral Structural Proteins - genetics
Virology
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Description
Summary:Two biotypes of pestiviruses, cytopathogenic (cp) and noncp viruses, can be distinguished by their effects on tissue culture cells. Identification of cp bovine viral diarrhea virus (BVDV) has been frequently reported since antigenically closely related noncp and cp BVDV can be isolated from cattle with fatal mucosal disease (MD) and are called a virus pair. In contrast to the BVDV system, only few cp border disease virus (BDV) and cp classical swine fever virus (CSFV) strains have been described. Serological analyses and sequence comparison studies showed that cp pestiviruses arise from noncp viruses by mutation. Elaborate studies during the last 10 years revealed that in most cases RNA recombination is responsible for the generation of the cp viruses. Recent results showed a second way for the development of a cp pestivirus which is based on the introduction of a set of point mutations within the NS2 gene.
ISSN:0378-1135
1873-2542
DOI:10.1016/S0378-1135(00)00268-6