Hantavirus Pulmonary Syndrome in Northern Alberta, Canada: Clinical and Laboratory Findings for 19 Cases

We reviewed the clinical and laboratory findings for 19 cases of hantavirus pulmonary syndrome (HPS) identified either serologically or by immunohistochemical testing of archival tissue at our tertiary care center. Fever (95%), cough (89%), and dyspnea (89%) were the most common presenting symptoms....

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Bibliographic Details
Published in:Clinical infectious diseases 2000-10, Vol.31 (4), p.942-946
Main Authors: Verity, R., Prasad, E., Grimsrud, K., Artsob, H., Drebot, M., Miedzinski, L., Preiksaitis, J.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Alberta - epidemiology
Animal viral diseases
Antibodies, Viral - blood
Biological and medical sciences
Blood
Disease outbreaks
Female
Hantavirus
Hantavirus - genetics
Hantavirus - immunology
Hantavirus - isolation & purification
Hantavirus pulmonary syndrome
Hantavirus Pulmonary Syndrome - diagnosis
Hantavirus Pulmonary Syndrome - mortality
Hantavirus Pulmonary Syndrome - virology
Humans
Immunoglobulin M - blood
Infectious diseases
Intubation
Lactates
Major Articles
Male
Medical sciences
Mice
Middle Aged
Mortality
Phylogeny
Seasons
Serologic Tests
Symptoms
Viral diseases
Viruses
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Summary:We reviewed the clinical and laboratory findings for 19 cases of hantavirus pulmonary syndrome (HPS) identified either serologically or by immunohistochemical testing of archival tissue at our tertiary care center. Fever (95%), cough (89%), and dyspnea (89%) were the most common presenting symptoms. The most prevalent presenting signs were respiratory abnormalities (95%) and tachycardia (84%). Common laboratory findings included thrombocytopenia (95%) and leukocytosis (79%). Elevated aspartate aminotransferase and lactate dehydrogenase levels were found in all patients tested. Intubation was required in 58% of the patients, and inotropic support was required in 53%. Our study confirms that serological responses appear early during clinical illness, making the enzyme immunoassay a useful tool for the diagnosis of acute HPS. The mortality (26%) and severity of disease that we observed among patients with HPS appear to be less than those reported elsewhere.
ISSN:1058-4838
1537-6591
DOI:10.1086/318137