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Hantavirus Pulmonary Syndrome in Northern Alberta, Canada: Clinical and Laboratory Findings for 19 Cases
We reviewed the clinical and laboratory findings for 19 cases of hantavirus pulmonary syndrome (HPS) identified either serologically or by immunohistochemical testing of archival tissue at our tertiary care center. Fever (95%), cough (89%), and dyspnea (89%) were the most common presenting symptoms....
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Published in: | Clinical infectious diseases 2000-10, Vol.31 (4), p.942-946 |
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container_title | Clinical infectious diseases |
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creator | Verity, R. Prasad, E. Grimsrud, K. Artsob, H. Drebot, M. Miedzinski, L. Preiksaitis, J. |
description | We reviewed the clinical and laboratory findings for 19 cases of hantavirus pulmonary syndrome (HPS) identified either serologically or by immunohistochemical testing of archival tissue at our tertiary care center. Fever (95%), cough (89%), and dyspnea (89%) were the most common presenting symptoms. The most prevalent presenting signs were respiratory abnormalities (95%) and tachycardia (84%). Common laboratory findings included thrombocytopenia (95%) and leukocytosis (79%). Elevated aspartate aminotransferase and lactate dehydrogenase levels were found in all patients tested. Intubation was required in 58% of the patients, and inotropic support was required in 53%. Our study confirms that serological responses appear early during clinical illness, making the enzyme immunoassay a useful tool for the diagnosis of acute HPS. The mortality (26%) and severity of disease that we observed among patients with HPS appear to be less than those reported elsewhere. |
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Fever (95%), cough (89%), and dyspnea (89%) were the most common presenting symptoms. The most prevalent presenting signs were respiratory abnormalities (95%) and tachycardia (84%). Common laboratory findings included thrombocytopenia (95%) and leukocytosis (79%). Elevated aspartate aminotransferase and lactate dehydrogenase levels were found in all patients tested. Intubation was required in 58% of the patients, and inotropic support was required in 53%. Our study confirms that serological responses appear early during clinical illness, making the enzyme immunoassay a useful tool for the diagnosis of acute HPS. The mortality (26%) and severity of disease that we observed among patients with HPS appear to be less than those reported elsewhere.</description><identifier>ISSN: 1058-4838</identifier><identifier>EISSN: 1537-6591</identifier><identifier>DOI: 10.1086/318137</identifier><identifier>PMID: 11049774</identifier><identifier>CODEN: CIDIEL</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>Adolescent ; Adult ; Aged ; Alberta - epidemiology ; Animal viral diseases ; Antibodies, Viral - blood ; Biological and medical sciences ; Blood ; Disease outbreaks ; Female ; Hantavirus ; Hantavirus - genetics ; Hantavirus - immunology ; Hantavirus - isolation & purification ; Hantavirus pulmonary syndrome ; Hantavirus Pulmonary Syndrome - diagnosis ; Hantavirus Pulmonary Syndrome - mortality ; Hantavirus Pulmonary Syndrome - virology ; Humans ; Immunoglobulin M - blood ; Infectious diseases ; Intubation ; Lactates ; Major Articles ; Male ; Medical sciences ; Mice ; Middle Aged ; Mortality ; Phylogeny ; Seasons ; Serologic Tests ; Symptoms ; Viral diseases ; Viruses</subject><ispartof>Clinical infectious diseases, 2000-10, Vol.31 (4), p.942-946</ispartof><rights>Copyright 2000 The Infectious Diseases Society of America</rights><rights>2000 by the Infectious Diseases Society of America 2000</rights><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c451t-fb699aa64c83bc6e951c1070ac8cd5326da8169dfad15c4ae74d4846675d51c93</citedby><cites>FETCH-LOGICAL-c451t-fb699aa64c83bc6e951c1070ac8cd5326da8169dfad15c4ae74d4846675d51c93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/4461342$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/4461342$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,58238,58471</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=800017$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11049774$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Verity, R.</creatorcontrib><creatorcontrib>Prasad, E.</creatorcontrib><creatorcontrib>Grimsrud, K.</creatorcontrib><creatorcontrib>Artsob, H.</creatorcontrib><creatorcontrib>Drebot, M.</creatorcontrib><creatorcontrib>Miedzinski, L.</creatorcontrib><creatorcontrib>Preiksaitis, J.</creatorcontrib><title>Hantavirus Pulmonary Syndrome in Northern Alberta, Canada: Clinical and Laboratory Findings for 19 Cases</title><title>Clinical infectious diseases</title><addtitle>Clinical Infectious Diseases</addtitle><addtitle>Clinical Infectious Diseases</addtitle><description>We reviewed the clinical and laboratory findings for 19 cases of hantavirus pulmonary syndrome (HPS) identified either serologically or by immunohistochemical testing of archival tissue at our tertiary care center. Fever (95%), cough (89%), and dyspnea (89%) were the most common presenting symptoms. The most prevalent presenting signs were respiratory abnormalities (95%) and tachycardia (84%). Common laboratory findings included thrombocytopenia (95%) and leukocytosis (79%). Elevated aspartate aminotransferase and lactate dehydrogenase levels were found in all patients tested. Intubation was required in 58% of the patients, and inotropic support was required in 53%. Our study confirms that serological responses appear early during clinical illness, making the enzyme immunoassay a useful tool for the diagnosis of acute HPS. The mortality (26%) and severity of disease that we observed among patients with HPS appear to be less than those reported elsewhere.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Alberta - epidemiology</subject><subject>Animal viral diseases</subject><subject>Antibodies, Viral - blood</subject><subject>Biological and medical sciences</subject><subject>Blood</subject><subject>Disease outbreaks</subject><subject>Female</subject><subject>Hantavirus</subject><subject>Hantavirus - genetics</subject><subject>Hantavirus - immunology</subject><subject>Hantavirus - isolation & purification</subject><subject>Hantavirus pulmonary syndrome</subject><subject>Hantavirus Pulmonary Syndrome - diagnosis</subject><subject>Hantavirus Pulmonary Syndrome - mortality</subject><subject>Hantavirus Pulmonary Syndrome - virology</subject><subject>Humans</subject><subject>Immunoglobulin M - blood</subject><subject>Infectious diseases</subject><subject>Intubation</subject><subject>Lactates</subject><subject>Major Articles</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Phylogeny</subject><subject>Seasons</subject><subject>Serologic Tests</subject><subject>Symptoms</subject><subject>Viral diseases</subject><subject>Viruses</subject><issn>1058-4838</issn><issn>1537-6591</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><recordid>eNqF0V1rFDEUBuBBFFur_gKRiOCVozmb796VwbrCWgUVpDfhbJKxU2cyazIj9t-bMsv2SrxK4H1yAu-pqqdA3wDV8i0DDUzdq45BMFVLYeB-uVOha66ZPqoe5XxNKYCm4mF1BEC5UYofV1drjBP-7tKcyee5H8aI6YZ8uYk-jUMgXSQXY5quQorkrN-GNOFr0mBEj6ek6bvYOewJRk82uB0TTmN5fd5F38UfmbRjImCKzyE_rh602OfwZH-eVN_O331t1vXm0_sPzdmmdlzAVLdbaQyi5E6zrZPBCHBAFUWnnRdsJT1qkMa36EE4jkFxzzWXUglfqGEn1atl7i6Nv-aQJzt02YW-xxjGOVu1YkJyw_4LQXMFTIg76NKYcwqt3aVuKDVZoPa2fLuUX-Dz_cR5OwR_x_ZtF_ByDzCX3tqE0XX54DQtG7od82JR47z791fPFnOdS-UHxbkExlclrpe4y1P4c4gx_bRSMSXs-vul1RswFw29tB_ZXxJtrIs</recordid><startdate>20001001</startdate><enddate>20001001</enddate><creator>Verity, R.</creator><creator>Prasad, E.</creator><creator>Grimsrud, K.</creator><creator>Artsob, H.</creator><creator>Drebot, M.</creator><creator>Miedzinski, L.</creator><creator>Preiksaitis, J.</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20001001</creationdate><title>Hantavirus Pulmonary Syndrome in Northern Alberta, Canada: Clinical and Laboratory Findings for 19 Cases</title><author>Verity, R. ; 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Fever (95%), cough (89%), and dyspnea (89%) were the most common presenting symptoms. The most prevalent presenting signs were respiratory abnormalities (95%) and tachycardia (84%). Common laboratory findings included thrombocytopenia (95%) and leukocytosis (79%). Elevated aspartate aminotransferase and lactate dehydrogenase levels were found in all patients tested. Intubation was required in 58% of the patients, and inotropic support was required in 53%. Our study confirms that serological responses appear early during clinical illness, making the enzyme immunoassay a useful tool for the diagnosis of acute HPS. The mortality (26%) and severity of disease that we observed among patients with HPS appear to be less than those reported elsewhere.</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>11049774</pmid><doi>10.1086/318137</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Adolescent Adult Aged Alberta - epidemiology Animal viral diseases Antibodies, Viral - blood Biological and medical sciences Blood Disease outbreaks Female Hantavirus Hantavirus - genetics Hantavirus - immunology Hantavirus - isolation & purification Hantavirus pulmonary syndrome Hantavirus Pulmonary Syndrome - diagnosis Hantavirus Pulmonary Syndrome - mortality Hantavirus Pulmonary Syndrome - virology Humans Immunoglobulin M - blood Infectious diseases Intubation Lactates Major Articles Male Medical sciences Mice Middle Aged Mortality Phylogeny Seasons Serologic Tests Symptoms Viral diseases Viruses |
title | Hantavirus Pulmonary Syndrome in Northern Alberta, Canada: Clinical and Laboratory Findings for 19 Cases |
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