Effects of acipimox on the lipolysis rate in subcutaneous adipose tissue of obese subjects

Background Acipimox is a hypolipidaemic agent reducing serum concentrations of triglycerides and non‐esterified fatty acids. Acipimox may reduce triglyceride synthesis by decreasing non‐esterified fatty acid availability from adipocytes, but this effect has yet to be demonstrated in vivo. Lipolysis...

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Published in:Diabetes/metabolism research and reviews 2001-09, Vol.17 (5), p.387-390
Main Authors: Flechtner-Mors, M., Jenkinson, C. P., Alt, A., Adler, G., Ditschuneit, H. H.
Format: Article
Language:English
Subjects:
Adipose Tissue - blood supply
Adipose Tissue - drug effects
Adipose Tissue - metabolism
Adult
Biological and medical sciences
Blood Flow Velocity
Female
Glycerol - blood
glycerol release
Humans
Hypolipidemic Agents - pharmacology
insulin resistance
Kinetics
Lipolysis - drug effects
Medical sciences
Metabolic diseases
Microdialysis
Middle Aged
Norepinephrine - pharmacology
Obesity
Obesity - metabolism
Pyrazines - pharmacology
severe obesity
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Summary:Background Acipimox is a hypolipidaemic agent reducing serum concentrations of triglycerides and non‐esterified fatty acids. Acipimox may reduce triglyceride synthesis by decreasing non‐esterified fatty acid availability from adipocytes, but this effect has yet to be demonstrated in vivo. Lipolysis after acipimox treatment was examined in subcutaneous adipose tissue of severely obese subjects with associated metabolic disorders. Methods The microdialysis technique was performed in abdominal subcutaneous adipose tissue of eight hyperinsulinaemic subjects. After oral treatment with acipimox, glycerol concentration was determined as an index of lipolysis rate. Blood flow was assessed by the ethanol escape technique. The rates of release of glycerol from human adipose tissue maximally stimulated by norepinephrine were also investigated in the presence of acipimox. Eight weight‐ and age‐matched subjects served as a control group. Results Under acipimox treatment, basal glycerol release decreased in subcutaneous adipose tissue, whereas no effect was observed on blood flow. In stimulated adipose tissue acipimox showed no effect. Conclusion In the present study basal glycerol outflow from adipose tissue was inhibited by acipimox. The anti‐lipolytic action of the agent may diminish elevated plasma concentrations of free fatty acids in subjects with severe obesity. Copyright © 2001 John Wiley & Sons, Ltd.
ISSN:1520-7552
1520-7560
DOI:10.1002/dmrr.219