Chorioallantoic membrane capillary bed: A useful target for studying angiogenesis and anti‐angiogenesis in vivo

The chick embryo chorioallantoic membrane (CAM) is an extraembryonic membrane that is commonly used in vivo to study both angiogenesis and anti‐angiogenesis. This review 1) summarizes the current knowledge about the structure of the CAM's capillary bed; 2) discusses the controversy about the ex...

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Bibliographic Details
Published in:The Anatomical record 2001-12, Vol.264 (4), p.317-324
Main Authors: Ribatti, Domenico, Nico, Beatrice, Vacca, Angelo, Roncali, Luisa, Burri, Peter H., Djonov, Valentin
Format: Article
Language:English
Subjects:
Allantois - blood supply
Allantois - embryology
Allantois - physiology
angiogenesis
Angiogenesis Inhibitors - physiology
Angiogenesis Inhibitors - therapeutic use
Animals
anti‐angiogenesis
Capillaries - anatomy & histology
Capillaries - physiology
Chick Embryo
chorioallantoic membrane
Chorion - blood supply
Chorion - embryology
Chorion - physiology
Fibroblast Growth Factor 2 - physiology
fibroblast growth factor‐2
intussusceptive growth
Models, Biological
Neoplasms - blood supply
Neoplasms - drug therapy
Neovascularization, Pathologic - drug therapy
Neovascularization, Physiologic - drug effects
Neovascularization, Physiologic - physiology
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Summary:The chick embryo chorioallantoic membrane (CAM) is an extraembryonic membrane that is commonly used in vivo to study both angiogenesis and anti‐angiogenesis. This review 1) summarizes the current knowledge about the structure of the CAM's capillary bed; 2) discusses the controversy about the existence of a single blood sinus or a capillary plexus underlying the chorionic epithelium; 3) describes a new model of the CAM vascular growth, namely the intussusceptive mode; 4) reports findings regarding the role played by endogenous fibroblast growth factor‐2 in CAM vascularization; and 5) addresses the use and limitations of the CAM as a model for studying angiogenesis and anti‐angiogenesis. Anat Rec 264:317–324, 2001. © 2001 Wiley‐Liss, Inc.
ISSN:0003-276X
1097-0185
DOI:10.1002/ar.10021