Failure of Pentavalent Antimony in Visceral Leishmaniasis in India: Report from the Center of the Indian Epidemic

In India, 320 patients with visceral leishmaniasis (209 in the state of Bihar and 11 in the neighboring state of Uttar Pradesh) received identical pentavalent antimony (Sb) treatment. Sb induced long-term cure in 35% (95% confidence interval [CI], 28%-42%) of those in Bihar versus 86% (95% CI, 79%-9...

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Bibliographic Details
Published in:Clinical infectious diseases 2000-10, Vol.31 (4), p.1104-1107
Main Authors: Sundar, Shyam, More, Deepak K., Singh, Manoj K., Singh, Vijay P., Sharma, Sashi, Makharia, Anand, Kumar, Prasanna C. K., Murray, Henry W.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Antimony
Antimony Sodium Gluconate - therapeutic use
Antiprotozoal Agents - therapeutic use
Biological and medical sciences
Bone marrow
Brief Reports
Child
Child, Preschool
Disease Outbreaks
Epidemics
Female
Human protozoal diseases
Humans
India - epidemiology
Infant
Infectious diseases
Leishmaniasis, Visceral - drug therapy
Leishmaniasis, Visceral - epidemiology
Leshmaniasis
Male
Medical sciences
Medical treatment failures
Middle Aged
Parasites
Parasitic diseases
Parasitism
Protozoal diseases
Relapse
Spleen
Symptoms
Treatment Failure
Tropical medicine
Visceral leishmaniasis
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Description
Summary:In India, 320 patients with visceral leishmaniasis (209 in the state of Bihar and 11 in the neighboring state of Uttar Pradesh) received identical pentavalent antimony (Sb) treatment. Sb induced long-term cure in 35% (95% confidence interval [CI], 28%-42%) of those in Bihar versus 86% (95% CI, 79%-93%) of those in Uttar Pradesh. In Bihar, the center of the Indian epidemic, traditional Sb treatment should be abandoned.
ISSN:1058-4838
1537-6591
DOI:10.1086/318121