Vitamin B12 deficiency—need for a new guideline

OBJECTIVES: Many patients with vitamin B12 deficiency do not have anemia or macrocytosis, but the prevalence of B12 deficiency in patients without macrocytosis is not known. METHODS: We investigated the prevalence of B12 deficiency among patients with normocytosis and microcytosis and recommended a...

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Published in:Nutrition (Burbank, Los Angeles County, Calif.) Los Angeles County, Calif.), 2001-11, Vol.17 (11), p.917-920
Main Authors: Chui, Chung Hin, Lau, Fung Yi, Wong, Raymond, Soo, Oi Yan, Lam, Chuk Kwan, Lee, Pui Wai, Leung, Ho Kei, So, Chiu Kui, Tsoi, Wai Chiu, Tang, Nelson, Lam, Wai Kei, Cheng, Gregory
Format: Article
Language:English
Subjects:
Age Factors
Aged
Anemia - epidemiology
Anemia, Macrocytic - epidemiology
Anemia, Pernicious - epidemiology
Anemias. Hemoglobinopathies
Biological and medical sciences
Blood Cell Count
China - epidemiology
Diseases of red blood cells
Female
Geriatric Assessment
Hematologic and hematopoietic diseases
Humans
Male
Mass Screening
Medical sciences
Metabolic diseases
Other nutritional diseases (malnutrition, nutritional and vitamin deficiencies...)
Prevalence
Retrospective Studies
screening guidelines
Vitamin B 12 - blood
Vitamin B 12 Deficiency - epidemiology
vitamin B12
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Summary:OBJECTIVES: Many patients with vitamin B12 deficiency do not have anemia or macrocytosis, but the prevalence of B12 deficiency in patients without macrocytosis is not known. METHODS: We investigated the prevalence of B12 deficiency among patients with normocytosis and microcytosis and recommended a screening strategy. All patients ( n = 3714) with serum B12 measured at the Prince of Wales Hospital in 1996 were reviewed. The prevalence of serum B12 less than 140 pmol/L was determined for the following patient subgroups: younger than 70 y, older than 70 y, anemic, non-anemic, macrocytic, normocytic, microcytic, documented iron deficiency, and documented thalassemia. RESULTS: The prevalence of B12 deficiency (
ISSN:0899-9007
1873-1244
DOI:10.1016/S0899-9007(01)00666-9