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Vitamin B12 deficiency—need for a new guideline
OBJECTIVES: Many patients with vitamin B12 deficiency do not have anemia or macrocytosis, but the prevalence of B12 deficiency in patients without macrocytosis is not known. METHODS: We investigated the prevalence of B12 deficiency among patients with normocytosis and microcytosis and recommended a...
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| Published in: | Nutrition (Burbank, Los Angeles County, Calif.) Los Angeles County, Calif.), 2001-11, Vol.17 (11), p.917-920 |
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| container_end_page | 920 |
| container_issue | 11 |
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| container_title | Nutrition (Burbank, Los Angeles County, Calif.) |
| container_volume | 17 |
| creator | Chui, Chung Hin Lau, Fung Yi Wong, Raymond Soo, Oi Yan Lam, Chuk Kwan Lee, Pui Wai Leung, Ho Kei So, Chiu Kui Tsoi, Wai Chiu Tang, Nelson Lam, Wai Kei Cheng, Gregory |
| description | OBJECTIVES: Many patients with vitamin B12 deficiency do not have anemia or macrocytosis, but the prevalence of B12 deficiency in patients without macrocytosis is not known.
METHODS: We investigated the prevalence of B12 deficiency among patients with normocytosis and microcytosis and recommended a screening strategy. All patients (
n = 3714) with serum B12 measured at the Prince of Wales Hospital in 1996 were reviewed. The prevalence of serum B12 less than 140 pmol/L was determined for the following patient subgroups: younger than 70 y, older than 70 y, anemic, non-anemic, macrocytic, normocytic, microcytic, documented iron deficiency, and documented thalassemia.
RESULTS: The prevalence of B12 deficiency ( |
| doi_str_mv | 10.1016/S0899-9007(01)00666-9 |
| format | article |
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METHODS: We investigated the prevalence of B12 deficiency among patients with normocytosis and microcytosis and recommended a screening strategy. All patients (
n = 3714) with serum B12 measured at the Prince of Wales Hospital in 1996 were reviewed. The prevalence of serum B12 less than 140 pmol/L was determined for the following patient subgroups: younger than 70 y, older than 70 y, anemic, non-anemic, macrocytic, normocytic, microcytic, documented iron deficiency, and documented thalassemia.
RESULTS: The prevalence of B12 deficiency (<140 pmol/L) ranged from 4.8% to 9.8% among the different subgroups.
CONCLUSIONS: Whatever screening criteria were used, a significant number of B12-deficient patients will be missed. Therefore, there may be a case for universal vitamin B12 screening.</description><identifier>ISSN: 0899-9007</identifier><identifier>EISSN: 1873-1244</identifier><identifier>DOI: 10.1016/S0899-9007(01)00666-9</identifier><identifier>PMID: 11744340</identifier><identifier>CODEN: NUTRER</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Age Factors ; Aged ; Anemia - epidemiology ; Anemia, Macrocytic - epidemiology ; Anemia, Pernicious - epidemiology ; Anemias. Hemoglobinopathies ; Biological and medical sciences ; Blood Cell Count ; China - epidemiology ; Diseases of red blood cells ; Female ; Geriatric Assessment ; Hematologic and hematopoietic diseases ; Humans ; Male ; Mass Screening ; Medical sciences ; Metabolic diseases ; Other nutritional diseases (malnutrition, nutritional and vitamin deficiencies...) ; Prevalence ; Retrospective Studies ; screening guidelines ; Vitamin B 12 - blood ; Vitamin B 12 Deficiency - epidemiology ; vitamin B12</subject><ispartof>Nutrition (Burbank, Los Angeles County, Calif.), 2001-11, Vol.17 (11), p.917-920</ispartof><rights>2001 Elsevier Science Inc.</rights><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c393t-c7b70fff6771b5e8f35aeb2a684b04561e2496037a878ae317b234f6fb2a1e9e3</citedby><cites>FETCH-LOGICAL-c393t-c7b70fff6771b5e8f35aeb2a684b04561e2496037a878ae317b234f6fb2a1e9e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13407506$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11744340$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chui, Chung Hin</creatorcontrib><creatorcontrib>Lau, Fung Yi</creatorcontrib><creatorcontrib>Wong, Raymond</creatorcontrib><creatorcontrib>Soo, Oi Yan</creatorcontrib><creatorcontrib>Lam, Chuk Kwan</creatorcontrib><creatorcontrib>Lee, Pui Wai</creatorcontrib><creatorcontrib>Leung, Ho Kei</creatorcontrib><creatorcontrib>So, Chiu Kui</creatorcontrib><creatorcontrib>Tsoi, Wai Chiu</creatorcontrib><creatorcontrib>Tang, Nelson</creatorcontrib><creatorcontrib>Lam, Wai Kei</creatorcontrib><creatorcontrib>Cheng, Gregory</creatorcontrib><title>Vitamin B12 deficiency—need for a new guideline</title><title>Nutrition (Burbank, Los Angeles County, Calif.)</title><addtitle>Nutrition</addtitle><description>OBJECTIVES: Many patients with vitamin B12 deficiency do not have anemia or macrocytosis, but the prevalence of B12 deficiency in patients without macrocytosis is not known.
METHODS: We investigated the prevalence of B12 deficiency among patients with normocytosis and microcytosis and recommended a screening strategy. All patients (
n = 3714) with serum B12 measured at the Prince of Wales Hospital in 1996 were reviewed. The prevalence of serum B12 less than 140 pmol/L was determined for the following patient subgroups: younger than 70 y, older than 70 y, anemic, non-anemic, macrocytic, normocytic, microcytic, documented iron deficiency, and documented thalassemia.
RESULTS: The prevalence of B12 deficiency (<140 pmol/L) ranged from 4.8% to 9.8% among the different subgroups.
CONCLUSIONS: Whatever screening criteria were used, a significant number of B12-deficient patients will be missed. Therefore, there may be a case for universal vitamin B12 screening.</description><subject>Age Factors</subject><subject>Aged</subject><subject>Anemia - epidemiology</subject><subject>Anemia, Macrocytic - epidemiology</subject><subject>Anemia, Pernicious - epidemiology</subject><subject>Anemias. Hemoglobinopathies</subject><subject>Biological and medical sciences</subject><subject>Blood Cell Count</subject><subject>China - epidemiology</subject><subject>Diseases of red blood cells</subject><subject>Female</subject><subject>Geriatric Assessment</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>Male</subject><subject>Mass Screening</subject><subject>Medical sciences</subject><subject>Metabolic diseases</subject><subject>Other nutritional diseases (malnutrition, nutritional and vitamin deficiencies...)</subject><subject>Prevalence</subject><subject>Retrospective Studies</subject><subject>screening guidelines</subject><subject>Vitamin B 12 - blood</subject><subject>Vitamin B 12 Deficiency - epidemiology</subject><subject>vitamin B12</subject><issn>0899-9007</issn><issn>1873-1244</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><recordid>eNqF0L1u2zAQwHGiSFA7bh6hhZYWyaD0TqRIcQoaI1-AgQ5NshIUdSxYyJJL2gm85SHyhH2Syh9Ixky3_I48_Bn7jHCGgPL7L6i0zjWAOgE8BZBS5voDG2OleI6FEAds_EpG7CilPwCAWuqPbISohOACxgwfwtLOQ5ddYJE15IML1Ln1v-eXjqjJfB8zm3X0lP1ehYba0NEnduhtm-h4Pyfs_urybnqTz35e305_zHLHNV_mTtUKvPdSKaxLqjwvLdWFlZWoQZQSqRBaAle2UpUljqouuPDSDwZJE5-wb7t3F7H_u6K0NPOQHLWt7ahfJaMKLqECPsByB13sU4rkzSKGuY1rg2A2rcy2ldmEMIBm28roYe_L_oNVPafmbWsfZwBf98AmZ1sfbedCenODUSXIwZ3vHA05HgNFk7YVqQmR3NI0fXjnlP9azoSn</recordid><startdate>20011101</startdate><enddate>20011101</enddate><creator>Chui, Chung Hin</creator><creator>Lau, Fung Yi</creator><creator>Wong, Raymond</creator><creator>Soo, Oi Yan</creator><creator>Lam, Chuk Kwan</creator><creator>Lee, Pui Wai</creator><creator>Leung, Ho Kei</creator><creator>So, Chiu Kui</creator><creator>Tsoi, Wai Chiu</creator><creator>Tang, Nelson</creator><creator>Lam, Wai Kei</creator><creator>Cheng, Gregory</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20011101</creationdate><title>Vitamin B12 deficiency—need for a new guideline</title><author>Chui, Chung Hin ; Lau, Fung Yi ; Wong, Raymond ; Soo, Oi Yan ; Lam, Chuk Kwan ; Lee, Pui Wai ; Leung, Ho Kei ; So, Chiu Kui ; Tsoi, Wai Chiu ; Tang, Nelson ; Lam, Wai Kei ; Cheng, Gregory</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c393t-c7b70fff6771b5e8f35aeb2a684b04561e2496037a878ae317b234f6fb2a1e9e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Age Factors</topic><topic>Aged</topic><topic>Anemia - epidemiology</topic><topic>Anemia, Macrocytic - epidemiology</topic><topic>Anemia, Pernicious - epidemiology</topic><topic>Anemias. Hemoglobinopathies</topic><topic>Biological and medical sciences</topic><topic>Blood Cell Count</topic><topic>China - epidemiology</topic><topic>Diseases of red blood cells</topic><topic>Female</topic><topic>Geriatric Assessment</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Humans</topic><topic>Male</topic><topic>Mass Screening</topic><topic>Medical sciences</topic><topic>Metabolic diseases</topic><topic>Other nutritional diseases (malnutrition, nutritional and vitamin deficiencies...)</topic><topic>Prevalence</topic><topic>Retrospective Studies</topic><topic>screening guidelines</topic><topic>Vitamin B 12 - blood</topic><topic>Vitamin B 12 Deficiency - epidemiology</topic><topic>vitamin B12</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chui, Chung Hin</creatorcontrib><creatorcontrib>Lau, Fung Yi</creatorcontrib><creatorcontrib>Wong, Raymond</creatorcontrib><creatorcontrib>Soo, Oi Yan</creatorcontrib><creatorcontrib>Lam, Chuk Kwan</creatorcontrib><creatorcontrib>Lee, Pui Wai</creatorcontrib><creatorcontrib>Leung, Ho Kei</creatorcontrib><creatorcontrib>So, Chiu Kui</creatorcontrib><creatorcontrib>Tsoi, Wai Chiu</creatorcontrib><creatorcontrib>Tang, Nelson</creatorcontrib><creatorcontrib>Lam, Wai Kei</creatorcontrib><creatorcontrib>Cheng, Gregory</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nutrition (Burbank, Los Angeles County, Calif.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chui, Chung Hin</au><au>Lau, Fung Yi</au><au>Wong, Raymond</au><au>Soo, Oi Yan</au><au>Lam, Chuk Kwan</au><au>Lee, Pui Wai</au><au>Leung, Ho Kei</au><au>So, Chiu Kui</au><au>Tsoi, Wai Chiu</au><au>Tang, Nelson</au><au>Lam, Wai Kei</au><au>Cheng, Gregory</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vitamin B12 deficiency—need for a new guideline</atitle><jtitle>Nutrition (Burbank, Los Angeles County, Calif.)</jtitle><addtitle>Nutrition</addtitle><date>2001-11-01</date><risdate>2001</risdate><volume>17</volume><issue>11</issue><spage>917</spage><epage>920</epage><pages>917-920</pages><issn>0899-9007</issn><eissn>1873-1244</eissn><coden>NUTRER</coden><abstract>OBJECTIVES: Many patients with vitamin B12 deficiency do not have anemia or macrocytosis, but the prevalence of B12 deficiency in patients without macrocytosis is not known.
METHODS: We investigated the prevalence of B12 deficiency among patients with normocytosis and microcytosis and recommended a screening strategy. All patients (
n = 3714) with serum B12 measured at the Prince of Wales Hospital in 1996 were reviewed. The prevalence of serum B12 less than 140 pmol/L was determined for the following patient subgroups: younger than 70 y, older than 70 y, anemic, non-anemic, macrocytic, normocytic, microcytic, documented iron deficiency, and documented thalassemia.
RESULTS: The prevalence of B12 deficiency (<140 pmol/L) ranged from 4.8% to 9.8% among the different subgroups.
CONCLUSIONS: Whatever screening criteria were used, a significant number of B12-deficient patients will be missed. Therefore, there may be a case for universal vitamin B12 screening.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>11744340</pmid><doi>10.1016/S0899-9007(01)00666-9</doi><tpages>4</tpages></addata></record> |
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| identifier | ISSN: 0899-9007 |
| ispartof | Nutrition (Burbank, Los Angeles County, Calif.), 2001-11, Vol.17 (11), p.917-920 |
| issn | 0899-9007 1873-1244 |
| language | eng |
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| source | ScienceDirect Journals |
| subjects | Age Factors Aged Anemia - epidemiology Anemia, Macrocytic - epidemiology Anemia, Pernicious - epidemiology Anemias. Hemoglobinopathies Biological and medical sciences Blood Cell Count China - epidemiology Diseases of red blood cells Female Geriatric Assessment Hematologic and hematopoietic diseases Humans Male Mass Screening Medical sciences Metabolic diseases Other nutritional diseases (malnutrition, nutritional and vitamin deficiencies...) Prevalence Retrospective Studies screening guidelines Vitamin B 12 - blood Vitamin B 12 Deficiency - epidemiology vitamin B12 |
| title | Vitamin B12 deficiency—need for a new guideline |
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