Effect of degree of blood pressure on the hypercoagulable state in chronic atrial fibrillation

To investigate the hypothesis that higher levels of blood pressure would further promote the hypercoagulable state in atrial fibrillation (AF) by increasing the degree of hemostatic abnormalities, we studied 82 consecutive patients with chronic nonvalvular AF who were not taking antithrombotic thera...

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Bibliographic Details
Published in:The American journal of cardiology 2000-10, Vol.86 (7), p.795-797
Main Authors: Li-Saw-Hee, Foo Leong, Blann, Andrew D, Lip, Gregory Y.H
Format: Article
Language:English
Subjects:
Aged
Atrial Fibrillation - blood
Atrial Fibrillation - physiopathology
Biological and medical sciences
Blood Coagulation - physiology
Blood pressure
Blood Pressure - physiology
Cardiac arrhythmia
Cardiac dysrhythmias
Cardiology
Cardiology. Vascular system
Chronic Disease
Drug therapy
Female
Fibrin Fibrinogen Degradation Products - metabolism
Fibrinogen - metabolism
Heart
Humans
Male
Medical sciences
Middle Aged
Risk Factors
von Willebrand Factor - metabolism
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Summary:To investigate the hypothesis that higher levels of blood pressure would further promote the hypercoagulable state in atrial fibrillation (AF) by increasing the degree of hemostatic abnormalities, we studied 82 consecutive patients with chronic nonvalvular AF who were not taking antithrombotic therapy. Patients with AF had higher levels of plasma fibrin D-dimer, von Willebrand factor, and fibrinogen than controls in sinus rhythm, and no differences between tertiles of either systolic, diastolic, or mean blood pressure were found, suggesting other mechanisms may be contributing to the hypercoagulable state in AF.
ISSN:0002-9149
1879-1913
DOI:10.1016/S0002-9149(00)01086-9