Treatment of Iatrogenic Femoral Artery Pseudoaneurysms Using Ultrasound-Guided Injection of Thrombin

• Published in: Clinical radiology 2000-10, Vol.55 (10), p.749-751
• Main Authors: HUGHES, MICHAEL J., McCALL, JAMES M., NOTT, DAVID M., PADLEY, SIMON P.G.
• Format: Article
• Language: English
• Subjects: Aneurysm, False - diagnostic imaging; Aneurysm, False - drug therapy; Aneurysm, False - etiology; Biological and medical sciences; Blood and lymphatic vessels; Cardiology. Vascular system; Catheterization, Peripheral - adverse effects; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous; Femoral Artery - diagnostic imaging; Hemostatics - therapeutic use; Humans; Iatrogenic Disease; Medical sciences; pseudoaneurysm, ultrasound, thrombin, angiography; Recurrence; Thrombin - therapeutic use; Treatment Outcome; Ultrasonography, Interventional
• ISSN: 0009-9260; 1365-229X
• DOI: 10.1053/crad.2000.0516

AIM: To evaluate the use of ultrasound-guided percutaneous injection of thrombin for treatment of femoral artery pseudoaneurysms. METHOD: Nine patients with a confirmed femoral false aneurysm were included in the study. 0.5–1ml of a 2000U/ml solution of activated bovine thrombin was injected under ultrasound visualization into the neck of the aneurysm to induce thrombosis. The parent artery and adjacent major vessels were checked during and after the procedure to exclude propagation of thrombus. A check ultrasound examination was undertaken on the following day. RESULTS: Eight patients were successfully treated by a single injection. One patient required a second injection due to recurrence of their pseudoaneurysm 4 days after the initial treatment. The procedure was well tolerated in all cases and no complications were encountered. CONCLUSION: This small series provides further evidence that ultrasound-guided thrombin injection is a promising new method for the treatment of femoral false aneurysms.Hughes, M. J. et al. (2000). Clinical Radiology55, 749–751.