Serum protein profiles of patients with pancreatic cancer and chronic pancreatitis: searching for a diagnostic protein pattern

In this study, 13 sera from patients with pancreatic cancer, 9 from chronic pancreatitis and 10 from healthy subjects were analyzed by matrix‐assisted laser desorption/ionization (MALDI) mass spectrometry. The MALDI mass spectra revealed the presence of several low molecular weight peptides, among w...

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Bibliographic Details
Published in:Rapid communications in mass spectrometry 2001-01, Vol.15 (24), p.2420-2425
Main Authors: Valerio, A., Basso, D., Mazza, S., Baldo, G., Tiengo, A., Pedrazzoli, S., Seraglia, R., Plebani, M.
Format: Article
Language:English
Subjects:
Aged
Biomarkers, Tumor
Blood Proteins - analysis
Chronic Disease
Female
Humans
Male
Middle Aged
Molecular Weight
Pancreatic Neoplasms - blood
Pancreatic Neoplasms - diagnosis
Pancreatitis - blood
Pancreatitis - diagnosis
Peptide Fragments - analysis
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
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Summary:In this study, 13 sera from patients with pancreatic cancer, 9 from chronic pancreatitis and 10 from healthy subjects were analyzed by matrix‐assisted laser desorption/ionization (MALDI) mass spectrometry. The MALDI mass spectra revealed the presence of several low molecular weight peptides, among which some were detected only in the sera from both pathological conditions. On the other hand many peptides were observed only in control sera, and were absent in the sera from the two diseases. Therefore, MALDI analysis of the low molecular weight fraction (
ISSN:0951-4198
1097-0231
DOI:10.1002/rcm.528