Expression of the c-fos gene during emotional stress in rats: the clocking effect of delta sleep-inducing peptide

• Published in: Neuroscience and behavioral physiology 2001-11, Vol.31 (6), p.635-640
• Main Authors: Sudakov, K V, Umryukhin, P E, Koplik, E V, Anokhin, K V
• Format: Article
• Language: English
• Subjects: Animals; Brain; Brain Chemistry - drug effects; Brain Chemistry - physiology; Cell Count; Conflict (Psychology); delta sleep-inducing peptide; Delta Sleep-Inducing Peptide - pharmacology; Emotions - physiology; Gene Expression Regulation - drug effects; Genes; Genes, fos - genetics; Hypothalamus; Image Processing, Computer-Assisted; Immobilization; Laboratories; Male; Paraventricular Hypothalamic Nucleus - cytology; Paraventricular Hypothalamic Nucleus - metabolism; Peptides; Rats; Rats, Wistar; Sleep; Stress, Psychological - genetics; Stress, Psychological - metabolism
• ISSN: 0097-0549; 1573-899X
• DOI: 10.1023/A:1012381413726

Emotional stress induced more marked increases in the expression of the c-fos gene in limbo-reticular structures of the brain in rats prognostically predisposed to emotional stress. I.p. doses of delta sleep-inducing peptide (DSIP) (60 nmol/kg) weakened the stress-induced expression of the c-fos gene. This effect was more apparent in animals predisposed to emotional stress, in which preliminary injections decreased stress-induced c-fos expression in the paraventricular hypothalamus and the medial and lateral parts of the septum. The decreased expression of the early gene c-fos in emotional stress after preliminary dosage with DSIP may reflect the leading mechanism of the anti-stress action of this peptide.