Impact of hyperthyroidism and its correction on vascular reactivity in humans

Although thyroid hormone (TH) exerts relevant effects on the cardiovascular system, it is unknown whether TH also regulates vascular reactivity in humans. Methods and Results- We studied 8 patients with hyperthyroidism, basally (H) and 6 months after euthyroidism was restored by methimazole (EU). Th...

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Published in:Circulation (New York, N.Y.) N.Y.), 2001-12, Vol.104 (25), p.3076-3080
Main Authors: NAPOLI, Raffaele, BIONDI, Bernadette, GUARDASOLE, Vincenzo, MATARAZZO, Margherita, PARDO, Francesco, ANGELINI, Valentina, FAZIO, Serafino, SACCA, Luigi
Format: Article
Language:English
Subjects:
Acetylcholine - pharmacology
Adult
Biological and medical sciences
Dose-Response Relationship, Drug
Endocrinopathies
Endothelium, Vascular - drug effects
Endothelium, Vascular - physiopathology
Enzyme Inhibitors - pharmacology
Female
Forearm - blood supply
Humans
Hyperthyroidism - physiopathology
Infusions, Intra-Arterial
Male
Medical sciences
Nitric Oxide Synthase - antagonists & inhibitors
Nitroprusside - pharmacology
Non tumoral diseases. Target tissue resistance. Benign neoplasms
Norepinephrine - pharmacology
omega-N-Methylarginine - pharmacology
Regional Blood Flow - drug effects
Thyroid. Thyroid axis (diseases)
Vasoconstrictor Agents - pharmacology
Vasodilator Agents - pharmacology
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Summary:Although thyroid hormone (TH) exerts relevant effects on the cardiovascular system, it is unknown whether TH also regulates vascular reactivity in humans. Methods and Results- We studied 8 patients with hyperthyroidism, basally (H) and 6 months after euthyroidism was restored by methimazole (EU). Thirteen healthy subjects served as control subjects (C). We measured forearm blood flow (FBF) by strain-gauge plethysmography during intrabrachial graded infusion of acetylcholine, sodium nitroprusside (SNP), norepinephrine, and L-NMMA (inhibitor of NO synthesis). Basal FBF (in mL. dL(-1). min(-1)) was markedly higher in H than in C (5.8+/-1.2 and 1.9+/-0.1, respectively; P
ISSN:0009-7322
1524-4539
DOI:10.1161/hc5001.100621