Subcellular distribution of aquaporin 5 in salivary glands in primary Sjögren's syndrome

Secretions from salivary and lacrimal glands are reduced in patients with primary Sjögren's syndrome (PSS). Since aquaporin 5 is involved in transport of water and is present in salivary and lacrimal glands, this protein was thought to have a major role in the pathogenesis of PSS. We used indir...

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Bibliographic Details
Published in:The Lancet (British edition) 2001-12, Vol.358 (9296), p.1875-1876
Main Authors: Beroukas, Dimitra, Hiscock, Jenny, Jonsson, Roland, Waterman, Sally A, Gordon, Tom P
Format: Article
Language:English
Subjects:
Animals
Antigens
Aquaporin 5
Aquaporins
Aquaporins - secretion
Biopsy
Case-Control Studies
Cytoplasm
Endocrine system
Fluorescent Antibody Technique, Indirect - methods
Gordon, Tom (baseball player)
Humans
Immunoenzyme Techniques
Immunofluorescence
Lacrimal Apparatus - metabolism
Lacrimal gland and Nasolacrimal duct
Medical disorders
Medical research
Membrane Proteins
Membranes
Pathogenesis
Patients
Peptides
Proteins
Rats
Salivary gland
Salivary glands
Salivary Glands - metabolism
Secretions
Sjogren's Syndrome - etiology
Sjogren's Syndrome - metabolism
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Summary:Secretions from salivary and lacrimal glands are reduced in patients with primary Sjögren's syndrome (PSS). Since aquaporin 5 is involved in transport of water and is present in salivary and lacrimal glands, this protein was thought to have a major role in the pathogenesis of PSS. We used indirect immunofluorescence and an immunoperoxidase technique to assess expression and subcellular localisation of aquaporin 5 in patients and controls. Our results suggest that the distribution and density of aquaporin 5 in salivary glands does not differ between patients with PSS and those without. Thus, the role of aquaporin 5 in the pathogenesis of PSS needs to be reassessed and alternative pathogenetic mechanisms investigated.
ISSN:0140-6736
1474-547X
DOI:10.1016/S0140-6736(01)06900-8