Antiretroviral therapy of HIV-1 infection: established treatment strategies and new therapeutic options

Recently, studies have shown that non-nucleoside reverse transcriptase inhibitors, such as efavirenz or nevirapine, in combination with two nucleoside analogues have an antiretroviral potency comparable to protease inhibitor containing regimens. Triple combination therapy that includes a non-nucleos...

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Bibliographic Details
Published in:Current Opinion in Microbiology 2000-10, Vol.3 (5), p.508-514
Main Authors: Kaufmann, Gilbert R, Cooper, David A
Format: Article
Language:English
Subjects:
Anti-HIV Agents - therapeutic use
Antiretroviral Therapy, Highly Active
efavirenz
HIV Infections - drug therapy
HIV Protease Inhibitors - therapeutic use
HIV-1
Human immunodeficiency virus 1
Humans
nevirapine
Reverse Transcriptase Inhibitors - therapeutic use
Salvage Therapy
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Summary:Recently, studies have shown that non-nucleoside reverse transcriptase inhibitors, such as efavirenz or nevirapine, in combination with two nucleoside analogues have an antiretroviral potency comparable to protease inhibitor containing regimens. Triple combination therapy that includes a non-nucleoside reverse transcriptase inhibitor can therefore be regarded as an effective alternative first-line treatment of HIV-1 infection.
ISSN:1369-5274
1879-0364
DOI:10.1016/S1369-5274(00)00131-4