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Synthesis of a Substance P Antagonist with a Somatostatin Scaffold: Factors Affecting Agonism/Antagonism at GPCRs and the Role of Pseudosymmetry

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Published in:	Journal of medicinal chemistry 2000-10, Vol.43 (21), p.3827-3831
Main Authors:	Liu, Josephine, Underwood, Dennis J, Cascieri, Margaret A, Rohrer, Susan P, Cantin, Louis-David, Chicchi, Gary, Smith, Amos B, Hirschmann, Ralph
Format:	Article
Language:	English
Subjects:	Animals Biological and medical sciences CHO Cells COS Cells Cricetinae Glucosides - chemical synthesis Glucosides - chemistry Glucosides - metabolism Glucosides - pharmacology Humans Medical sciences Membrane Proteins Molecular Mimicry Neurokinin-1 Receptor Antagonists Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Peptidergic system (neuropeptide, opioid peptide, opiates...). Adenosinergic and purinergic systems Pharmacology. Drug treatments Receptors, Neurokinin-1 - metabolism Receptors, Somatostatin - agonists Receptors, Somatostatin - antagonists & inhibitors Receptors, Somatostatin - metabolism Somatostatin - agonists Somatostatin - chemistry Substance P - antagonists & inhibitors
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doi_str_mv	10.1021/jm000316h
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source	American Chemical Society:Jisc Collections:American Chemical Society Read & Publish Agreement 2022-2024 (Reading list)
subjects	Animals Biological and medical sciences CHO Cells COS Cells Cricetinae Glucosides - chemical synthesis Glucosides - chemistry Glucosides - metabolism Glucosides - pharmacology Humans Medical sciences Membrane Proteins Molecular Mimicry Neurokinin-1 Receptor Antagonists Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Peptidergic system (neuropeptide, opioid peptide, opiates...). Adenosinergic and purinergic systems Pharmacology. Drug treatments Receptors, Neurokinin-1 - metabolism Receptors, Somatostatin - agonists Receptors, Somatostatin - antagonists & inhibitors Receptors, Somatostatin - metabolism Somatostatin - agonists Somatostatin - chemistry Substance P - antagonists & inhibitors
title	Synthesis of a Substance P Antagonist with a Somatostatin Scaffold: Factors Affecting Agonism/Antagonism at GPCRs and the Role of Pseudosymmetry
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