Mangifera indica L. extract (QF808) reduces ischaemia-induced neuronal loss and oxidative damage in the gerbil brain

The effect of oral administration of Mangifera indica L. extract (QF808) on ischemia-reperfusion-induced neuronal death in the gerbil hippocampal CA1 sector was examined. Oral administration of QF808 for 7 days dose-dependently protected against neuronal cell death following transient ischaemia and...

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Bibliographic Details
Published in:Free radical research 2001-01, Vol.35 (5), p.465-473
Main Authors: Sánchez, Gregorio Martínez, Candelario-Jalil, Eduardo, Giuliani, Attilia, León, Olga-Sonia, Sam, Susana, Delgado, Rene, Núñez Sellés, Alberto J.
Format: Article
Language:English
Subjects:
Animals
Antioxidant activity
Antioxidants - pharmacology
Brain - drug effects
Brain - metabolism
Brain - pathology
Brain Ischemia - drug therapy
Brain Ischemia - metabolism
Brain Ischemia - pathology
Cell Death - drug effects
Cerebral Cortex - drug effects
Cerebral Cortex - metabolism
Cerebral Cortex - pathology
Gerbil
Gerbillinae
Ischaemia-reperfusion
Magnoliopsida
Male
Mangifera indica L
Motor Activity - drug effects
Neurons - drug effects
Neurons - pathology
Neuroprotection
Phytotherapy
Plant Extracts - pharmacology
Pyramidal Cells - drug effects
Pyramidal Cells - metabolism
Pyramidal Cells - pathology
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Summary:The effect of oral administration of Mangifera indica L. extract (QF808) on ischemia-reperfusion-induced neuronal death in the gerbil hippocampal CA1 sector was examined. Oral administration of QF808 for 7 days dose-dependently protected against neuronal cell death following transient ischaemia and reperfusion as assessed by histopathology. In addition, locomotor activity assessment prior to ischaemia and 7 days after correlated well with the histological results. To evaluate redox alterations by reactive oxygen species, total sulfhydryl, non-protein sulfhydryl groups (NPSH), malondialdehyde+4-hydroxyalkenals and total nitrogen oxide levels were assayed in hippocampus and cortex homogenates. QF808 treatment attenuated NPSH loss, nitrogen oxide levels and lipid peroxidation in the hippocampus. These results suggest that orally administered QF808 is absorbed across the blood-brain barrier and attenuates neuronal death of the hippocampal CA1 area after ischaemia-reperfusion. These protective effects are most likely due to the antioxidant activity of QF808.
ISSN:1071-5762
1029-2470
DOI:10.1080/10715760100301481