Synthesis and evaluation of microtubule assembly inhibition and cytotoxicity of prenylated derivatives of cyclo- l-Trp- l-Pro

The synthesis of three isoprenylated derivatives of cyclo- l-Trp- l-Pro is described. These substances have been evaluated for cytotoxic activity in rat normal fibroblast 3Y1 cells and have also been evaluated in vitro for the inhibition of microtubule assembly.

Saved in:
Bibliographic Details
Published in:Bioorganic & medicinal chemistry 2000-10, Vol.8 (10), p.2407-2415
Main Authors: Sanz-Cervera, Juan F, Stocking, Emily M, Usui, Takeo, Osada, Hiroyuki, Williams, Robert M
Format: Article
Language:English
Subjects:
Animals
Antineoplastic agents
Biological and medical sciences
Cattle
Cells, Cultured - drug effects
Fibroblasts - drug effects
General aspects
Indole Alkaloids
Indoles - pharmacology
Medical sciences
Microtubule-Associated Proteins - analysis
Microtubules - drug effects
Mitosis - drug effects
Molecular Structure
Peptides, Cyclic - chemical synthesis
Peptides, Cyclic - pharmacology
Pharmacology. Drug treatments
Piperazines
Protein Prenylation
Rats
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The synthesis of three isoprenylated derivatives of cyclo- l-Trp- l-Pro is described. These substances have been evaluated for cytotoxic activity in rat normal fibroblast 3Y1 cells and have also been evaluated in vitro for the inhibition of microtubule assembly.
ISSN:0968-0896
1464-3391
DOI:10.1016/S0968-0896(00)00171-1