Patterns of Fos Expression in the Amygdala and Ventral Perirhinal Cortex Induced by Training in an Olfactory Fear Conditioning Paradigm

The activation of amygdaloid nuclei, the ventral perirhinal cortex (vPRh), and several other brain areas in the rat during the acquisition and expression of olfactory fear conditioning was assessed through Fos immunocytochemistry in 3 separate experiments. The results of Experiment 1 suggest that ol...

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Bibliographic Details
Published in:Behavioral neuroscience 2001-12, Vol.115 (6), p.1257-1272
Main Authors: Schettino, Luis F, Otto, Tim
Format: Article
Language:English
Subjects:
Amygdala
Amygdala - physiology
Anatomical correlates of behavior
Animal
Animal behavior
Animals
Avoidance Learning
Behavioral psychophysiology
Biological and medical sciences
Brain
Cerebral Cortex - physiology
Conditioned Responses
Fear
Fundamental and applied biological sciences. Psychology
Gene Expression Regulation
Genes, fos
Immunohistochemistry
Immunoreactivity
Male
Neurology
Olfactory Bulb
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Rats
Rats, Sprague-Dawley
Rodents
Smell
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Summary:The activation of amygdaloid nuclei, the ventral perirhinal cortex (vPRh), and several other brain areas in the rat during the acquisition and expression of olfactory fear conditioning was assessed through Fos immunocytochemistry in 3 separate experiments. The results of Experiment 1 suggest that olfactory and somatosensory inputs may functionally converge in the anterior region of the medial nucleus (aMe). The results of Experiment 2 indicate that the aMe exhibited significantly greater Fos-like immunoreactivity (FLI) in subjects acquiring conditioned stimulus-unconditioned stimulus associations than in those presented with the same olfactory and somatosensory stimuli in a manner that precluded acquisition. The results of Experiment 3 indicate that the vPRh appeared to exhibit learning-related increases in FLI during the expression of previously acquired associations. Collectively, these data suggest that the aMe and vPRh may be critically involved in different aspects of olfactory fear conditioning.
ISSN:0735-7044
1939-0084
DOI:10.1037/0735-7044.115.6.1257