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Patterns of Fos Expression in the Amygdala and Ventral Perirhinal Cortex Induced by Training in an Olfactory Fear Conditioning Paradigm
The activation of amygdaloid nuclei, the ventral perirhinal cortex (vPRh), and several other brain areas in the rat during the acquisition and expression of olfactory fear conditioning was assessed through Fos immunocytochemistry in 3 separate experiments. The results of Experiment 1 suggest that ol...
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| Published in: | Behavioral neuroscience 2001-12, Vol.115 (6), p.1257-1272 |
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| Language: | English |
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| container_end_page | 1272 |
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| container_title | Behavioral neuroscience |
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| creator | Schettino, Luis F Otto, Tim |
| description | The activation
of amygdaloid nuclei, the ventral perirhinal cortex (vPRh), and several other
brain areas in the rat during the acquisition and expression of olfactory fear
conditioning was assessed through Fos immunocytochemistry in 3 separate
experiments. The results of Experiment 1 suggest that olfactory and
somatosensory inputs may functionally converge in the anterior region of the
medial nucleus (aMe). The results of Experiment 2 indicate that the aMe
exhibited significantly greater Fos-like immunoreactivity (FLI) in subjects
acquiring conditioned stimulus-unconditioned stimulus associations
than in those presented with the same olfactory and somatosensory stimuli in a
manner that precluded acquisition. The results of Experiment 3 indicate that the
vPRh appeared to exhibit learning-related increases in FLI during the expression
of previously acquired associations. Collectively, these data suggest that the
aMe and vPRh may be critically involved in different aspects of olfactory fear
conditioning. |
| doi_str_mv | 10.1037/0735-7044.115.6.1257 |
| format | article |
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of amygdaloid nuclei, the ventral perirhinal cortex (vPRh), and several other
brain areas in the rat during the acquisition and expression of olfactory fear
conditioning was assessed through Fos immunocytochemistry in 3 separate
experiments. The results of Experiment 1 suggest that olfactory and
somatosensory inputs may functionally converge in the anterior region of the
medial nucleus (aMe). The results of Experiment 2 indicate that the aMe
exhibited significantly greater Fos-like immunoreactivity (FLI) in subjects
acquiring conditioned stimulus-unconditioned stimulus associations
than in those presented with the same olfactory and somatosensory stimuli in a
manner that precluded acquisition. The results of Experiment 3 indicate that the
vPRh appeared to exhibit learning-related increases in FLI during the expression
of previously acquired associations. Collectively, these data suggest that the
aMe and vPRh may be critically involved in different aspects of olfactory fear
conditioning.</description><identifier>ISSN: 0735-7044</identifier><identifier>EISSN: 1939-0084</identifier><identifier>DOI: 10.1037/0735-7044.115.6.1257</identifier><identifier>PMID: 11770057</identifier><identifier>CODEN: BENEDJ</identifier><language>eng</language><publisher>Washington, DC: American Psychological Association</publisher><subject>Amygdala ; Amygdala - physiology ; Anatomical correlates of behavior ; Animal ; Animal behavior ; Animals ; Avoidance Learning ; Behavioral psychophysiology ; Biological and medical sciences ; Brain ; Cerebral Cortex - physiology ; Conditioned Responses ; Fear ; Fundamental and applied biological sciences. Psychology ; Gene Expression Regulation ; Genes, fos ; Immunohistochemistry ; Immunoreactivity ; Male ; Neurology ; Olfactory Bulb ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; Rats ; Rats, Sprague-Dawley ; Rodents ; Smell</subject><ispartof>Behavioral neuroscience, 2001-12, Vol.115 (6), p.1257-1272</ispartof><rights>2001 American Psychological Association</rights><rights>2002 INIST-CNRS</rights><rights>Copyright American Psychological Association Dec 2001</rights><rights>2001, American Psychological Association</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a364t-7d366281b83de254aeaaf9f06544b62e8706e4d8e4bf757e4a9b4d6c4cd6355a3</citedby><cites>FETCH-LOGICAL-a364t-7d366281b83de254aeaaf9f06544b62e8706e4d8e4bf757e4a9b4d6c4cd6355a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13383617$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11770057$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schettino, Luis F</creatorcontrib><creatorcontrib>Otto, Tim</creatorcontrib><title>Patterns of Fos Expression in the Amygdala and Ventral Perirhinal Cortex Induced by Training in an Olfactory Fear Conditioning Paradigm</title><title>Behavioral neuroscience</title><addtitle>Behav Neurosci</addtitle><description>The activation
of amygdaloid nuclei, the ventral perirhinal cortex (vPRh), and several other
brain areas in the rat during the acquisition and expression of olfactory fear
conditioning was assessed through Fos immunocytochemistry in 3 separate
experiments. The results of Experiment 1 suggest that olfactory and
somatosensory inputs may functionally converge in the anterior region of the
medial nucleus (aMe). The results of Experiment 2 indicate that the aMe
exhibited significantly greater Fos-like immunoreactivity (FLI) in subjects
acquiring conditioned stimulus-unconditioned stimulus associations
than in those presented with the same olfactory and somatosensory stimuli in a
manner that precluded acquisition. The results of Experiment 3 indicate that the
vPRh appeared to exhibit learning-related increases in FLI during the expression
of previously acquired associations. Collectively, these data suggest that the
aMe and vPRh may be critically involved in different aspects of olfactory fear
conditioning.</description><subject>Amygdala</subject><subject>Amygdala - physiology</subject><subject>Anatomical correlates of behavior</subject><subject>Animal</subject><subject>Animal behavior</subject><subject>Animals</subject><subject>Avoidance Learning</subject><subject>Behavioral psychophysiology</subject><subject>Biological and medical sciences</subject><subject>Brain</subject><subject>Cerebral Cortex - physiology</subject><subject>Conditioned Responses</subject><subject>Fear</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Expression Regulation</subject><subject>Genes, fos</subject><subject>Immunohistochemistry</subject><subject>Immunoreactivity</subject><subject>Male</subject><subject>Neurology</subject><subject>Olfactory Bulb</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Rodents</subject><subject>Smell</subject><issn>0735-7044</issn><issn>1939-0084</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><recordid>eNqF0c1q3DAUBWBTWppp2jcoRRSanaeS9Wcvw5BJA4HMIu1WXFvXEwVbdiUNxE-Q165Nhk7pol1Ji-_ci3Sy7COja0a5_ko1l7mmQqwZk2u1ZoXUr7IVq3iVU1qK19nqNznL3sX4SCkVVMi32RljWlMq9Sp73kFKGHwkQ0u2QyRXT2PAGN3gifMkPSC57Ke9hQ4IeEt-oE8BOrLD4MKD8_N1M4SET-TG20ODltQTuQ_gvPP7ZQJ4cte10KQhTGSLEGbvrUvzgkXsIIB1-_599qaFLuKH43mefd9e3W--5bd31zeby9scuBIp15YrVZSsLrnFQgpAgLZqqZJC1KrAUlOFwpYo6lZLjQKqWljViMYqLiXw8-ziZe4Yhp8HjMn0LjbYdeBxOESjC665kOV_IdNFUUnJZ_j5L_g4HML8MdEoJnjJFJP_QgXl1dwgVTMSL6gJQ4wBWzMG10OYDKNm6dwshZqlUDMnjDJL53Ps03H2oe7RnkLHkmfw5QggNtC1AXzj4slxXnLF9OnJMIIZ49RASK7pMJra458bfwFh58Bp</recordid><startdate>200112</startdate><enddate>200112</enddate><creator>Schettino, Luis F</creator><creator>Otto, Tim</creator><general>American Psychological Association</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QR</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7RZ</scope><scope>PSYQQ</scope><scope>7X8</scope></search><sort><creationdate>200112</creationdate><title>Patterns of Fos Expression in the Amygdala and Ventral Perirhinal Cortex Induced by Training in an Olfactory Fear Conditioning Paradigm</title><author>Schettino, Luis F ; Otto, Tim</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a364t-7d366281b83de254aeaaf9f06544b62e8706e4d8e4bf757e4a9b4d6c4cd6355a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Amygdala</topic><topic>Amygdala - physiology</topic><topic>Anatomical correlates of behavior</topic><topic>Animal</topic><topic>Animal behavior</topic><topic>Animals</topic><topic>Avoidance Learning</topic><topic>Behavioral psychophysiology</topic><topic>Biological and medical sciences</topic><topic>Brain</topic><topic>Cerebral Cortex - physiology</topic><topic>Conditioned Responses</topic><topic>Fear</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Expression Regulation</topic><topic>Genes, fos</topic><topic>Immunohistochemistry</topic><topic>Immunoreactivity</topic><topic>Male</topic><topic>Neurology</topic><topic>Olfactory Bulb</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. Psychophysiology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Rodents</topic><topic>Smell</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schettino, Luis F</creatorcontrib><creatorcontrib>Otto, Tim</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>PsycArticles (via ProQuest)</collection><collection>ProQuest One Psychology</collection><collection>MEDLINE - Academic</collection><jtitle>Behavioral neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schettino, Luis F</au><au>Otto, Tim</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Patterns of Fos Expression in the Amygdala and Ventral Perirhinal Cortex Induced by Training in an Olfactory Fear Conditioning Paradigm</atitle><jtitle>Behavioral neuroscience</jtitle><addtitle>Behav Neurosci</addtitle><date>2001-12</date><risdate>2001</risdate><volume>115</volume><issue>6</issue><spage>1257</spage><epage>1272</epage><pages>1257-1272</pages><issn>0735-7044</issn><eissn>1939-0084</eissn><coden>BENEDJ</coden><abstract>The activation
of amygdaloid nuclei, the ventral perirhinal cortex (vPRh), and several other
brain areas in the rat during the acquisition and expression of olfactory fear
conditioning was assessed through Fos immunocytochemistry in 3 separate
experiments. The results of Experiment 1 suggest that olfactory and
somatosensory inputs may functionally converge in the anterior region of the
medial nucleus (aMe). The results of Experiment 2 indicate that the aMe
exhibited significantly greater Fos-like immunoreactivity (FLI) in subjects
acquiring conditioned stimulus-unconditioned stimulus associations
than in those presented with the same olfactory and somatosensory stimuli in a
manner that precluded acquisition. The results of Experiment 3 indicate that the
vPRh appeared to exhibit learning-related increases in FLI during the expression
of previously acquired associations. Collectively, these data suggest that the
aMe and vPRh may be critically involved in different aspects of olfactory fear
conditioning.</abstract><cop>Washington, DC</cop><pub>American Psychological Association</pub><pmid>11770057</pmid><doi>10.1037/0735-7044.115.6.1257</doi><tpages>16</tpages></addata></record> |
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| ispartof | Behavioral neuroscience, 2001-12, Vol.115 (6), p.1257-1272 |
| issn | 0735-7044 1939-0084 |
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| source | EBSCOhost APA PsycARTICLES |
| subjects | Amygdala Amygdala - physiology Anatomical correlates of behavior Animal Animal behavior Animals Avoidance Learning Behavioral psychophysiology Biological and medical sciences Brain Cerebral Cortex - physiology Conditioned Responses Fear Fundamental and applied biological sciences. Psychology Gene Expression Regulation Genes, fos Immunohistochemistry Immunoreactivity Male Neurology Olfactory Bulb Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Rats Rats, Sprague-Dawley Rodents Smell |
| title | Patterns of Fos Expression in the Amygdala and Ventral Perirhinal Cortex Induced by Training in an Olfactory Fear Conditioning Paradigm |
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