Fibrinogen polymorphisms are not associated with the risk of myocardial infarction

In the Study of Myocardial Infarctions Leiden, we investigated the prevalence of three polymorphisms in the α‐ and β‐fibrinogen genes among 560 patients with a myocardial infarction and 646 control subjects. Secondly, we studied the relationships between these polymorphisms and fibrinogen activity a...

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Bibliographic Details
Published in:British journal of haematology 2000-09, Vol.110 (4), p.935-938
Main Authors: Doggen, C. J. M., Bertina, R. M., Cats, V. Manger, Rosendaal, F. R.
Format: Article
Language:English
Subjects:
aetiology
Analysis of Variance
Biological and medical sciences
Cardiology. Vascular system
Case-Control Studies
Chi-Square Distribution
Coronary heart disease
fibrinogen
Fibrinogen - genetics
Genotype
Heart
Hematology
Humans
Male
Medical sciences
Middle Aged
myocardial infarction
Myocardial Infarction - etiology
Myocardial Infarction - genetics
Polymorphism, Genetic
polymorphisms
Risk
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Summary:In the Study of Myocardial Infarctions Leiden, we investigated the prevalence of three polymorphisms in the α‐ and β‐fibrinogen genes among 560 patients with a myocardial infarction and 646 control subjects. Secondly, we studied the relationships between these polymorphisms and fibrinogen activity and antigen levels. The TaqI, HaeIII and BclI polymorphisms in the fibrinogen gene were not associated with myocardial infarction. As we found an association of the rare B2 allele with fibrinogen levels and a similar, but weak, effect for the rare H2 allele, we conclude that a genetic propensity to high fibrinogen levels does not affect the risk of myocardial infarction. This is evidence against a causal role for fibrinogen levels in the aetiology of myocardial infarction.
ISSN:0007-1048
1365-2141
DOI:10.1046/j.1365-2141.2000.02266.x