Maspin expression in stage I and II oral tongue squamous cell carcinoma

• Published in: Head & neck 2001-11, Vol.23 (11), p.962-966
• Main Authors: Yasumatsu, Ryuji, Nakashima, Torahiko, Hirakawa, Naoya, Kumamoto, Yoshihiko, Kuratomi, Yuichiro, Tomita, Kichinobu, Komiyama, Sohtaro
• Format: Article
• Language: English
• Subjects: Adult; Aged; Aged, 80 and over; Biological and medical sciences; Brachytherapy; Carcinoma, Squamous Cell - drug therapy; Carcinoma, Squamous Cell - metabolism; Carcinoma, Squamous Cell - mortality; Carcinoma, Squamous Cell - radiotherapy; Carcinoma, Squamous Cell - secondary; Disease-Free Survival; early tongue carcinoma; Female; Genes, Tumor Suppressor; Humans; Immunohistochemistry; Male; maspin; Medical sciences; metastasis; Middle Aged; Otorhinolaryngology. Stomatology; Prognosis; Proteins - metabolism; serine protease inhibitor; Serine Proteinase Inhibitors - metabolism; Serpins - metabolism; Tongue Neoplasms - drug therapy; Tongue Neoplasms - metabolism; Tongue Neoplasms - mortality; Tongue Neoplasms - pathology; Tongue Neoplasms - radiotherapy; Tumors; Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology
• ISSN: 1043-3074; 1097-0347
• DOI: 10.1002/hed.1139

Background A relatively high failure rate in the therapy of patients with early oral tongue squamous cell carcinomas (SCCs) is evidenced by untreated clinically negative neck lymph node metastasis. It is important to predict the malignant potential of oral tongue SCC in stage I and II patients, because the development of lymph node metastasis directly affects the prognosis of the patients. Methods We evaluated maspin expression immunohistochemically in patients with stage I and II oral tongue SCCs and determined whether the expression level may be a useful factor in predicting metastatic potential and prognosis of these SCCs. Results Clinical follow‐up data showed a longer disease‐free interval and overall survival periods for tumors immunohistochemically positive for maspin than for tumors negative for maspin, with the difference in disease‐free interval being statistically significant (p = .01). The absence of maspin expression was found more frequently in cases of subsequent cervical lymph node metastasis than in cases without metastasis (p = .03). Conclusions Decreased maspin expression may be a significant factor associated with the metastatic potential of stage I and II oral tongue SCCs. © 2001 John Wiley & Sons, Inc. Head Neck 23: 962–966, 2001.