In vivo role of CLC chloride channels in the kidney

Chloride channels in the kidney are involved in important physiological functions such as cell volume regulation, acidification of intracellular vesicles, and transepithelial chloride transport. Among eight mammalian CLC chloride channels expressed in the kidney, three (CLC-K1, CLC-K2, and CLC-5) we...

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Bibliographic Details
Published in:American journal of physiology. Renal physiology 2000-11, Vol.279 (5), p.F802-F808
Main Author: Uchida, S
Format: Article
Language:English
Subjects:
Animals
Anion Transport Proteins
Bartter Syndrome - genetics
Chloride Channels - genetics
Chloride Channels - metabolism
Diabetes Insipidus, Nephrogenic - genetics
Humans
Kidney - metabolism
Kidney Diseases - genetics
Kidney Diseases - metabolism
Membrane Proteins
Mice
Mice, Knockout
Rats
Xenopus laevis
Xenopus Proteins
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Summary:Chloride channels in the kidney are involved in important physiological functions such as cell volume regulation, acidification of intracellular vesicles, and transepithelial chloride transport. Among eight mammalian CLC chloride channels expressed in the kidney, three (CLC-K1, CLC-K2, and CLC-5) were identified to be related to kidney diseases in humans or mice. CLC-K1 mediates a transepithelial chloride transport in the thin ascending limb of Henle's loop and is essential for urinary concentrating mechanisms. CLC-K2 is a basolateral chloride channel in distal nephron segments and is necessary for chloride reabsorption. CLC-5 is a chloride channel in intracellular vesicles of proximal tubules and is involved in endocytosis. This review will cover the recent advances in research on the CLC chloride channels of the kidney with a special focus on the issues most necessary to understand their physiological roles in vivo, i.e., their intrarenal and cellular localization and their phenotypes of humans and mice that have their loss-of-function mutations.
ISSN:1931-857X
1522-1466
DOI:10.1152/ajprenal.2000.279.5.f802