Association of beta2-adrenoceptor Gln27Glu variant with body weight but not hypertension

Beta2-adrenoceptor (beta2-ADR)-mediated vasodilatation decreases vascular reactivity and blood pressure (BP) and chromosome 5 where its gene (ADRB2R) resides and shows linkage to hypertension (HT). A Gln27Glu ADRB2R variant confers resistance to agonist-induced desensitization and enhanced vasodilat...

Full description

Saved in:
Bibliographic Details
Published in:American journal of hypertension 2001-12, Vol.14 (12), p.1201-1204
Main Authors: Lin RCY, Ericsson, J O, Benjafield, A V, Morris, B J
Format: Article
Language:English
Subjects:
Body Weight - genetics
Case-Control Studies
Chromosomes, Human, Pair 5
Cohort Studies
Genetic Markers
Genetic Predisposition to Disease
Genotype
Glutamic Acid - genetics
Glutamine - genetics
Humans
Hypertension - epidemiology
Hypertension - genetics
Obesity - epidemiology
Obesity - genetics
Receptors, Adrenergic, beta-2 - genetics
Risk Factors
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Beta2-adrenoceptor (beta2-ADR)-mediated vasodilatation decreases vascular reactivity and blood pressure (BP) and chromosome 5 where its gene (ADRB2R) resides and shows linkage to hypertension (HT). A Gln27Glu ADRB2R variant confers resistance to agonist-induced desensitization and enhanced vasodilator response to isoprenaline. Therefore, we carried out a case-control study in a cohort of HT and normotensive (NT) Anglo-Celtic Australian white subjects whose parents had a similar BP status as the subjects. Glu27 frequency was 0.41 in 108 HT and 0.42 in 141 NT (chi2 = 0.05, P = .82). Within the HT group, the Glu27 allele was more prevalent in 61 subjects who were overweight (body mass index [BMI] > or = 25 kg/m2) compared with 41 who were lean (BMI
ISSN:0895-7061