Role of lipopolysaccharide susceptibility in the innate immune response to Salmonella typhimurium infection: LPS, a primary target for recognition of Gram-negative bacteria

Lipopolysaccharide is an important recognition marker by virtue of which the innate immune system senses and reacts against Gram-negative bacteria invading the LPS susceptible host. This review deals with the factors affecting LPS susceptibility and with the role of the latter in the course and outc...

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Bibliographic Details
Published in:Microbes and infection 2001-11, Vol.3 (14), p.1213-1222
Main Authors: Freudenberg, Marina A, Merlin, Thomas, Gumenscheimer, Marina, Kalis, Christoph, Landmann, Regine, Galanos, Chris
Format: Article
Language:English
Subjects:
Animals
CD14
Gram-Negative Bacteria - immunology
Gram-Negative Bacteria - pathogenicity
Humans
IFN-γ
IL-12
Immunity, Innate
lipopolysaccharides
Lipopolysaccharides - immunology
Lipopolysaccharides - metabolism
Lipopolysaccharides - pharmacology
lps gene
LPS susceptibility
LPS-binding protein
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Salmonella Infections, Animal - immunology
Salmonella Infections, Animal - microbiology
Salmonella typhimurium
Salmonella typhimurium - immunology
Salmonella typhimurium - pathogenicity
Salmonella typhimurium infection
TLR4
TNF-α
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Summary:Lipopolysaccharide is an important recognition marker by virtue of which the innate immune system senses and reacts against Gram-negative bacteria invading the LPS susceptible host. This review deals with the factors affecting LPS susceptibility and with the role of the latter in the course and outcome of Salmonella typhimurium infection.
ISSN:1286-4579
1769-714X
DOI:10.1016/S1286-4579(01)01481-2