Synthesis and anti-microbial activities of some pyridinium salts with alkoxymethyl hydrophobic group

A novel class of functionalised cationic surfactant has been obtained. The work-up procedure of synthesis is very simple, the yield is high and the pyridinium salts with alkoxymethyl hydrophobic group are easily purified. All the salts examined showed anti-microbial activities. Some of them exhibite...

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Bibliographic Details
Published in:European journal of medicinal chemistry 2001-12, Vol.36 (11), p.899-907
Main Authors: Pernak, Juliusz, Kalewska, Joanna, Ksycińska, Hanna, Cybulski, Jacek
Format: Article
Language:English
Subjects:
alkoxymethylation
Anti-Bacterial Agents
Anti-Infective Agents - chemical synthesis
Anti-Infective Agents - chemistry
Anti-Infective Agents - pharmacology
anti-microbial activities
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Bacteria - drug effects
Biological and medical sciences
Fungi - drug effects
Medical sciences
Microbial Sensitivity Tests
nicotinamide
Pharmacology. Drug treatments
Pyridinium Compounds - chemical synthesis
Pyridinium Compounds - chemistry
Pyridinium Compounds - pharmacology
pyridium salts
QSAR analysis
Quantitative Structure-Activity Relationship
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Summary:A novel class of functionalised cationic surfactant has been obtained. The work-up procedure of synthesis is very simple, the yield is high and the pyridinium salts with alkoxymethyl hydrophobic group are easily purified. All the salts examined showed anti-microbial activities. Some of them exhibited strong activity and wide anti-bacterial spectra similar to the activity of benzalkonium chloride. The relationship between chemical structure and anti-microbial activity was analysed by the QSAR method.
ISSN:0223-5234
1768-3254
DOI:10.1016/S0223-5234(01)01280-6