Effect of hormone replacement therapy on age-related increase in carotid artery intima-media thickness in postmenopausal women

The aim of this study was to determine the changes in carotid artery intima-media thickness as measured by B-mode ultrasound in postmenopausal women receiving hormone replacement therapy (HRT) or not. One hundred and fifty-nine healthy postmenopausal women aged 45–65 years were recruited from our me...

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Bibliographic Details
Published in:Atherosclerosis 2000-11, Vol.153 (1), p.81-88
Main Authors: Tremollieres, Florence A., Cigagna, Fabienne, Alquier, Cathy, Cauneille, Colette, Pouilles, Jean-Michel, Ribot, Claude
Format: Article
Language:English
Subjects:
Aged
Aging - physiology
B-mode ultrasound
Biological and medical sciences
Carotid Arteries - diagnostic imaging
Carotid Arteries - drug effects
Estrogen Replacement Therapy
Female
Hormone replacement therapy
Hormones. Endocrine system
Humans
Intima-media thickness
Lipids - blood
Medical sciences
Menopause
Middle Aged
Pharmacology. Drug treatments
Postmenopause
Tunica Intima - diagnostic imaging
Tunica Intima - drug effects
Tunica Media - diagnostic imaging
Tunica Media - drug effects
Ultrasonography
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Summary:The aim of this study was to determine the changes in carotid artery intima-media thickness as measured by B-mode ultrasound in postmenopausal women receiving hormone replacement therapy (HRT) or not. One hundred and fifty-nine healthy postmenopausal women aged 45–65 years were recruited from our menopause clinic. All the selected women were free of cardio-vascular diseases and had no cardio-vascular risk factors. None of the women were receiving lipid-lowering or antihypertensive drugs. Because carotid artery intima-media thickness was shown to be strongly and positively correlated with age in women aged 55 years and older but not before, women were divided into four groups according to age (
ISSN:0021-9150
1879-1484
DOI:10.1016/S0021-9150(00)00372-5