Soluble receptors for tumor necrosis factor-α (TNF-R p55 and TNF-R p75) in familial combined hyperlipidemia

We investigated the potential role of the 75 kD receptor for tumor necrosis factor-α (TNF-α) ( TNFRSF1B, located on chromosome 1 band p36.2) as a modifier gene in familial combined hyperlipidemia (FCH), based on previous linkage and association data. Age-corrected values for the soluble (s) extracel...

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Bibliographic Details
Published in:Atherosclerosis 2000-11, Vol.153 (1), p.1-8
Main Authors: van Greevenbroek, Marleen M.J., van der Kallen, Carla J.H., Geurts, Jan M.W., Janssen, Rob G.J.H., Buurman, Wim A., de Bruin, Tjerk W.A.
Format: Article
Language:English
Subjects:
Adult
Aged
Antigens, CD - blood
Biological and medical sciences
Disorders
Disorders of blood lipids. Hyperlipoproteinemia
Female
Genetic
Humans
Hyperlipidemia, Familial Combined - blood
Insulin resistance
Lipids - blood
Male
Medical sciences
Metabolic diseases
Middle Aged
Osmolar Concentration
Prognosis
Receptors, Tumor Necrosis Factor - blood
Receptors, Tumor Necrosis Factor, Type I
Receptors, Tumor Necrosis Factor, Type II
Reference Values
Regression analysis
Solubility
Tnf-sr55
Tnf-sr75
TNFRSF1B
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Summary:We investigated the potential role of the 75 kD receptor for tumor necrosis factor-α (TNF-α) ( TNFRSF1B, located on chromosome 1 band p36.2) as a modifier gene in familial combined hyperlipidemia (FCH), based on previous linkage and association data. Age-corrected values for the soluble (s) extracellular domain of TNF-R p75 were lower in 156 well-characterized hyperlipidemic (HL) FCH relatives than in 168 normolipidemic (NL) relatives ( P
ISSN:0021-9150
1879-1484
DOI:10.1016/S0021-9150(00)00375-0