Solid phase synthesis of mixture-based acyclic and heterocyclic small molecule combinatorial libraries from resin-bound polyamides

The development of soluble mixture‐based heterocyclic combinatorial libraries derived from amino acids and peptides is described. Starting with a “toolbox” of various chemical transformations, including alkylations, reductions, acylations, and the use of a variety of bifunctional reagents, the “libr...

Full description

Saved in:
Bibliographic Details
Published in:Biopolymers 2001, Vol.60 (3), p.212-219
Main Authors: Nefzi, Adel, Ostresh, John M., Houghten, Richard A.
Format: Article
Language:English
Subjects:
Combinatorial Chemistry Techniques
combinatorial libraries
Guanidine - chemistry
heterocyclic compounds
libraries from libraries
Lysine - chemistry
Models, Chemical
Peptide Biosynthesis
Peptide Library
Peptides - chemical synthesis
Peptides - chemistry
polyamines
small molecule compounds
solid phase synthesis
Thiourea - chemistry
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The development of soluble mixture‐based heterocyclic combinatorial libraries derived from amino acids and peptides is described. Starting with a “toolbox” of various chemical transformations, including alkylations, reductions, acylations, and the use of a variety of bifunctional reagents, the “libraries from libraries” concept has been expanded to encompass the development of more than fifty positional scanning combinatorial libraries each composed of tens of thousands of low molecular weight acyclic and heterocyclic compounds. © 2001 John Wiley & Sons, Inc. Biopolymers (Pept Sci) 60: 212–219, 2001
ISSN:0006-3525
1097-0282
DOI:10.1002/1097-0282(2001)60:3<212::AID-BIP10033>3.0.CO;2-D