Controversies in the use of antenatal steroids for fetal maturation

After decades of caution and reticence, by the early 1990s, the use of antenatal corticosteroids was accepted as a pharmacologic intervention to reduce neonatal morbidity and mortality associated with prematurity. Many prospective studies yielded robust evidence to support the use of corticosteroids...

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Bibliographic Details
Published in:Seminars in perinatology 2001-12, Vol.25 (6), p.385-396
Main Authors: Vidaeff, Alex C., Mastrobattista, Joan M.
Format: Article
Language:English
Subjects:
Animals
Brain - drug effects
Brain - embryology
Female
Fetal Membranes, Premature Rupture
Fetal Organ Maturity
Gestational Age
Glucocorticoids - administration & dosage
Glucocorticoids - adverse effects
Humans
Infant, Newborn
Infant, Premature
Obstetric Labor, Premature
Pregnancy
Time Factors
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Summary:After decades of caution and reticence, by the early 1990s, the use of antenatal corticosteroids was accepted as a pharmacologic intervention to reduce neonatal morbidity and mortality associated with prematurity. Many prospective studies yielded robust evidence to support the use of corticosteroids for fetal maturation. Their use is no longer disputed. Nevertheless, many unanswered questions remain regarding issues such as the ideal dose, drug form, regimen, or timing of treatment. This article explores many of the unanswered questions associated with antenatal corticosteroid use.
ISSN:0146-0005
1558-075X
DOI:10.1053/sper.2001.29039