Matching peptide mass spectra to EST and genomic DNA databases

The use of mass spectrometry data to search molecular sequence databases is a well-established method for protein identification. The technique can be extended to searching raw genomic sequences, providing experimental confirmation or correction of predicted coding sequences, and has the potential t...

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Bibliographic Details
Published in:Trends in Biotechnology 2001-10, Vol.19 (10 Suppl), p.17-22
Main Authors: Choudhary, Jyoti S, Blackstock, Walter P, Creasy, David M, Cottrell, John S
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Artemis
Databases, Nucleic Acid
EST
Expressed Sequence Tags
genomics
Genomics - methods
Genomics - trends
human genome
Mascot
mass spectrometry
Mass Spectrometry - methods
Molecular Sequence Data
MSDB
Peptides - analysis
Peptides - chemistry
Peptides - genetics
protein identification
Software
UniGene
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Description
Summary:The use of mass spectrometry data to search molecular sequence databases is a well-established method for protein identification. The technique can be extended to searching raw genomic sequences, providing experimental confirmation or correction of predicted coding sequences, and has the potential to identify novel genes and elucidate splicing patterns.
ISSN:0167-7799
1879-3096
DOI:10.1016/S0167-7799(01)00004-X