A case of successful fetal therapy for congenital chylothorax by intrapleural injection of OK‐432

A 38‐year‐old multiparous woman was referred at 19 weeks' gestation because of hydrops fetalis. Ultrasonic examination revealed severe pleural effusion, ascites and skin edema. Detailed examination of the amniotic fluid, fetal blood and intrathoracic fluid led to a diagnosis of congenital fetal...

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Bibliographic Details
Published in:Ultrasound in obstetrics & gynecology 2001-10, Vol.18 (4), p.371-375
Main Authors: Tanemura, M., Nishikawa, N., Kojima, K., Suzuki, Y., Suzumori, K.
Format: Article
Language:English
Subjects:
Adhesion
Adult
Antineoplastic Agents - administration & dosage
Antineoplastic Agents - therapeutic use
Biological and medical sciences
Chylothorax - diagnostic imaging
Chylothorax - drug therapy
Chylothorax - embryology
Congenital chylothorax
Diseases of mother, fetus and pregnancy
Female
Fetal Diseases - drug therapy
Gynecology. Andrology. Obstetrics
Humans
Hydrops fetalis
Injections, Intralesional
Medical sciences
OK‐432
Picibanil - administration & dosage
Picibanil - therapeutic use
Pleural effusion
Pleural Effusion - diagnostic imaging
Pleural Effusion - drug therapy
Pleural Effusion - embryology
Pleurodesis
Pregnancy
Pregnancy. Fetus. Placenta
Pulmonary hypoplasia
Ultrasonography, Prenatal
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Summary:A 38‐year‐old multiparous woman was referred at 19 weeks' gestation because of hydrops fetalis. Ultrasonic examination revealed severe pleural effusion, ascites and skin edema. Detailed examination of the amniotic fluid, fetal blood and intrathoracic fluid led to a diagnosis of congenital fetal chylothorax. Repeated thoracocenteses were not effective in improving the hydrops fetalis. We introduced fetal treatment for the pleural effusion by an intrapleural injection of OK‐432 at 23, 24 and 25 weeks' gestation. The pleural effusion was reduced by adhesion of the intrathoracic space and resulted in the delivery of a neonate who was healthy except for right renal dysfunction. Pulmonary hypoplasia was successfully prevented by OK‐432. Copyright © 2001 International Society of Ultrasound in Obstetrics and Gynecology
ISSN:0960-7692
1469-0705
DOI:10.1046/j.0960-7692.2001.00536.x