Hyaluronan: polysaccharide chaos to protein organisation

Molecular dynamics simulations of hyaluronan have revealed the inherent flexibility of this glycosaminoglycan in solution. Crystal structures of hyaluronan-digesting enzymes have provided the first direct insights into the molecular basis of hyaluronan–protein interactions. Various studies on hyalur...

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Bibliographic Details
Published in:Current Opinion in Structural Biology 2001-10, Vol.11 (5), p.617-622
Main Authors: Day, Anthony J, Sheehan, John K
Format: Article
Language:English
Subjects:
Carbohydrate Conformation
hyaladherins
Hyaluronan
Hyaluronan Receptors - chemistry
Hyaluronic Acid - chemistry
link module superfamily
Macromolecular Substances
Models, Molecular
polysaccharide conformation and dynamics
Polysaccharide-Lyases - chemistry
Protein Binding
protein-carbohydrate interactions
Solutions
Thermodynamics
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Summary:Molecular dynamics simulations of hyaluronan have revealed the inherent flexibility of this glycosaminoglycan in solution. Crystal structures of hyaluronan-digesting enzymes have provided the first direct insights into the molecular basis of hyaluronan–protein interactions. Various studies on hyaluronan-binding proteins suggest there is considerable diversity in their mode of interaction with hyaluronan, which might result in many different bound conformations of the polysaccharide.
ISSN:0959-440X
1879-033X
DOI:10.1016/S0959-440X(00)00256-6