Endothelin-1 synthesis reduced by red wine

Statistical evidence of reduced coronary heart disease in areas of high wine consumption has led to the widespread belief that wine affords a protective effect. Although moderate drinking of any alcohol helps to reduce the incidence of coronary heart disease, there is no clear evidence that red wine...

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Bibliographic Details
Published in:Nature (London) 2001-12, Vol.414 (6866), p.863-864
Main Authors: CORDER, Roger, DOUTHWAITE, Julie A, LEES, Delphine M, KHAN, Noorafza Q, VISEU DOS SANTOS, Ana Carolina, WOOD, Elizabeth G, CARRIER, Martin J
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Cattle
Cells, Cultured
Coronary Artery Disease - etiology
Coronary Artery Disease - prevention & control
Diet
Endothelin-1 - biosynthesis
Endothelin-1 - genetics
Endothelin-1 - physiology
Flavonoids
Fundamental and applied biological sciences. Psychology
Gene Expression Regulation
Humans
Molecular and cellular biology
Phenols - pharmacology
Phosphorylation
Polymers - pharmacology
Polyphenols
Protein-Tyrosine Kinases - antagonists & inhibitors
Protein-Tyrosine Kinases - metabolism
Wine
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Summary:Statistical evidence of reduced coronary heart disease in areas of high wine consumption has led to the widespread belief that wine affords a protective effect. Although moderate drinking of any alcohol helps to reduce the incidence of coronary heart disease, there is no clear evidence that red wine confers an additional benefit. Here we show that red wines strongly inhibit the synthesis of endothelin-1, a vasoactive peptide that is crucial in the development of coronary atherosclerosis. Our findings indicate that components specific to red wine may help to prevent coronary heart disease.
ISSN:0028-0836
1476-4687
DOI:10.1038/414863a