The pigmentotropic hormone [His 7]-corazonin, absent in a Locusta migratoria albino strain, occurs in an albino strain of Schistocerca gregaria

[His 7]-corazonin has recently been identified in the corpora cardiaca (CC) of two locust species, the migratory locust, Locusta migratoria and the desert locust, Schistocerca gregaria, as the dark colour inducing neurohormone. Here, we investigate whether [His 7]-corazonin occurs in the brain-CC ax...

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Bibliographic Details
Published in:Molecular and cellular endocrinology 2000-10, Vol.168 (1), p.101-109
Main Authors: Schoofs, Liliane, Baggerman, Geert, Veelaert, Dirk, Breuer, Michael, Tanaka, Seiji, De Loof, Arnold
Format: Article
Language:English
Subjects:
Albinism
Animals
Brain - anatomy & histology
Brain - metabolism
Brain Chemistry
Chromatography, High Pressure Liquid
Corazonin
Corpora cardiaca
Dark colour inducing hormone
Electrospray ionisation double quadrupole time of flight mass spectrometry
Grasshoppers - chemistry
Grasshoppers - metabolism
Immunohistochemistry
Insect Hormones - analysis
Insect Hormones - metabolism
Insect Proteins
Locusta migratoria
Mass Spectrometry
Mutation
neurohormones
Neuropeptides - chemistry
Neuropeptides - immunology
Neuropeptides - metabolism
Neurosecretory Systems - anatomy & histology
Neurosecretory Systems - chemistry
Neurosecretory Systems - metabolism
Pigmentation
Schistocerca gregaria
Tissue Extracts - chemistry
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Summary:[His 7]-corazonin has recently been identified in the corpora cardiaca (CC) of two locust species, the migratory locust, Locusta migratoria and the desert locust, Schistocerca gregaria, as the dark colour inducing neurohormone. Here, we investigate whether [His 7]-corazonin occurs in the brain-CC axis of a Schistocerca albino strain. From data obtained by immunocytochemistry, injection experiments, chromatographic and mass spectrometric analysis of brain and CC tissues, it could be concluded that an albino strain of S. gregaria from Denmark contains authentic [His 7]-corazonin. This was unequivocally demonstrated by sequencing the [His 7]-corazonin-immunoreactive factor in albino Schistocerca brain-CC extracts with ESI-Qq-oa-TOF mass spectrometry. Albinism in this strain is hence not caused by the deficiency of authentic [His 7]-corazonin in the brain-CC axis, nor by defects in release. Conversely to L. migratoria albinos, injection of [His 7]-corazonin failed to induce dark pigmentation in Schistocerca albinos. Therefore, albinism in the investigated Schistocerca strain is likely to be situated at the level of the receptor, signal transduction mechanisms or of pigment biosynthesis.
ISSN:0303-7207
1872-8057
DOI:10.1016/S0303-7207(00)00306-3