Minimally invasive evaluation of coronary microvascular function by electron beam computed tomography

We previously demonstrated that in vivo electron-beam computed tomography (EBCT)-based indicator-dilution methods provide an estimate of intramyocardial blood volume (BV) and perfusion (F), which relate as BV=aF+b radicalF, where a characterizes the recruitable (exchange) and b the nonrecruitable (c...

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Published in:Circulation (New York, N.Y.) N.Y.), 2000-11, Vol.102 (19), p.2411-2416
Main Authors: MÖHLENKAMP, Stefan, LERMAN, Lilach O, LERMAN, Amir, BEHRENBECK, Thomas R, KATUSIC, Zvonimir S, SHEEDY, Patrick F, RITMAN, Erik L
Format: Article
Language:English
Subjects:
Adenosine - pharmacology
Animals
Biological and medical sciences
Cardiovascular system
Coronary Circulation - physiology
Coronary Vessels - physiology
Hypercholesterolemia - diagnosis
Hypercholesterolemia - physiopathology
Investigative techniques, diagnostic techniques (general aspects)
Medical sciences
Microcirculation - physiology
Nitroglycerin - pharmacology
Radiodiagnosis. Nmr imagery. Nmr spectrometry
Regional Blood Flow - drug effects
Regional Blood Flow - physiology
Swine
Tomography, X-Ray Computed - methods
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Summary:We previously demonstrated that in vivo electron-beam computed tomography (EBCT)-based indicator-dilution methods provide an estimate of intramyocardial blood volume (BV) and perfusion (F), which relate as BV=aF+b radicalF, where a characterizes the recruitable (exchange) and b the nonrecruitable (conduit) component of the myocardial microcirculation. In the present study, we compared BV and F with intracoronary Doppler ultrasound-based coronary blood flow (CBF) as a method for detecting and quantifying differential responses of these microvascular components to vasoactive drugs in normal (control) and hypercholesterolemic (HC) pigs. BV and F values were obtained from contrast-enhanced EBCT studies in 14 HC and 14 control pigs. BV, F, and CBF values were obtained at baseline (intracoronary infusion of saline) and after 5 minutes each of intracoronary infusion of adenosine (100 microgram. kg(-1). min(-1)) and nitroglycerin (40 microgram/min). BV and CBF reserves in response to adenosine were attenuated in HC pigs compared with controls (90+/-36% versus 127+/-42%, P
ISSN:0009-7322
1524-4539
DOI:10.1161/01.cir.102.19.2411