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Computed tomography 21 days after chemotherapy, three‐dimensional estimates of metastatic volume and the need for surgery in patients with germ cell cancer

Objective To assess whether the response visible on computed tomography (CT) 21 days after the first course of chemotherapy in patients with nonseminomatous germ cell tumour predicts the need for surgery and whether three‐dimensional (3D) reconstruction adds to the diagnostic accuracy. Patients and...

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Bibliographic Details
Published in:BJU international 2000-10, Vol.86 (6), p.707-713
Main Authors: Bozcuk, H.S., Ravi, R., Turner, B., Tsetis, D., Thomas, J.M., Chan, O., Reznek, R., Hendry, W.F., Oliver, R.T.D.
Format: Article
Language:English
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Summary:Objective To assess whether the response visible on computed tomography (CT) 21 days after the first course of chemotherapy in patients with nonseminomatous germ cell tumour predicts the need for surgery and whether three‐dimensional (3D) reconstruction adds to the diagnostic accuracy. Patients and methods CT scans from 52 patients treated with cisplatin‐based chemotherapy were assessed for tumour shrinkage by measuring the changes of a one‐dimensional (1D) measurement of the maximum transverse diameter, and comparing CT scans before, 21 days after the first course and at the end of chemotherapy (1D method). In a subset of patients, using a special formula, the 1D‐derived 2D and 3D shrinkage (2Dder and 3Dder) were compared with four other computed or calculated methods (1D, 2D, 3Dcalc, 3Dcomp). Results At day 21, in 32 of 52 patients (62%) there was  50% tumour shrinkage by day 21 (χ2 = 22.83, P 
ISSN:1464-4096
1464-410X
DOI:10.1046/j.1464-410x.2000.00864.x