Variations in Biological Features of West Nile Viruses

: Pathological findings in humans, horses, and birds with West Nile (WN) encephalitis show neuronal degeneration and necrosis in the central nervous system (CNS), with diffuse inflammation. The mechanisms of WN viral penetration of the CNS and pathophysiology of the encephalitis remain largely unkno...

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Bibliographic Details
Published in:Annals of the New York Academy of Sciences 2001-12, Vol.951 (1), p.195-206
Main Authors: DEUBEL, V., FIETTE, L., GOUNON, P., DROUET, M. T., KHUN, H., HUERRE, M., BANET, C., MALKINSON, M., DESPRÈS, P.
Format: Article
Language:English
Subjects:
Aedes - virology
Animals
Birds - virology
central nervous system
flavivirus infection
Haplorhini - virology
Horses - virology
Humans
Mice - virology
West Nile Fever - pathology
West Nile virus
West Nile virus - pathogenicity
West Nile virus - ultrastructure
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Summary:: Pathological findings in humans, horses, and birds with West Nile (WN) encephalitis show neuronal degeneration and necrosis in the central nervous system (CNS), with diffuse inflammation. The mechanisms of WN viral penetration of the CNS and pathophysiology of the encephalitis remain largely unknown. Since 1996, several epizootics involving hundreds of humans, horses, and thousands of wild and domestic bird cases of encephalitis and mortality have been reported in Europe, North Africa, the Middle East, Russia, and the USA (see specific chapters in this issue). However, biological and molecular markers of virus virulence should be characterized to assess whether novel strains with increased virulence are responsible for this recent proliferation of outbreaks.
ISSN:0077-8923
1749-6632
DOI:10.1111/j.1749-6632.2001.tb02697.x