Cell Compartmentalization in Redox Signaling

From a growing body of evidence on the role of Reactive Oxygen Species as intracellular signaling molecules, the concept starts to emerge that cell responses to redox changes are function of the intracellular site where oxidants are produced and/or meet their molecular targets. In particular,a major...

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Bibliographic Details
Published in:IUBMB life 2001-07, Vol.52 (1), p.7-16
Main Authors: Pani, Giovambattista, Bedogni, Barbara, Colavitti, Renata, Anzevino, Rosanna, Borrello, Silvia, Galeotti, Tommaso
Format: Article
Language:English
Subjects:
Animals
Apoptosis
Cell Compartmentation
Cell Respiration
Cellular Senescence
Humans
Mitochondria
Mitochondria - metabolism
Mnsod
NADPH Oxidases - metabolism
Oncogenes
Oxidation-Reduction
Oxidative Stress
ras Proteins - metabolism
Reactive Oxygen Species
Signal Transduction
Superoxides - metabolism
Tumor Necrosis Factor-alpha - metabolism
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Summary:From a growing body of evidence on the role of Reactive Oxygen Species as intracellular signaling molecules, the concept starts to emerge that cell responses to redox changes are function of the intracellular site where oxidants are produced and/or meet their molecular targets. In particular,a major distinction between oxidative events in the cytosolic versus the mitochondrial compartment appears to exist in terms of physiological stimuli, signaling mechanisms and functional consequences. Experimental data supporting this view are reviewed here, and the potential implications of this new perspective in redox signaling are discussed.
ISSN:1521-6543
1521-6551
DOI:10.1080/15216540252774702