Inaccuracy of clinical phenotyping parameters for hypertensive nephrosclerosis

Background. Multiple studies suggest that hypertension‐induced end‐stage renal disease (ESRD) is heritable. Identification of nephropathy susceptibility genes absolutely requires accurate phenotyping, but the clinical hypertensive nephrosclerosis (HN) phenotype is poorly characterized. We hypothesiz...

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Published in:Nephrology, dialysis, transplantation dialysis, transplantation, 2000-11, Vol.15 (11), p.1801-1807
Main Authors: Zarif, Linda, Covic, Adrian, Iyengar, Sudha, Sehgal, Ashwini R., Sedor, John R., Schelling, Jeffrey R.
Format: Article
Language:English
Subjects:
Arterial hypertension. Arterial hypotension
Biological and medical sciences
Black or African American
Black People - genetics
Blood and lymphatic vessels
Cardiology. Vascular system
Clinical manifestations. Epidemiology. Investigative techniques. Etiology
Diabetes Mellitus, Type 1 - physiopathology
Diabetes Mellitus, Type 2 - physiopathology
Diabetic Nephropathies - genetics
Diabetic Nephropathies - physiopathology
diagnosis
ESRD
genes
Genetic Predisposition to Disease
Humans
hypertension
Kidney Failure, Chronic - genetics
Medical sciences
nephropathy
Nephrosclerosis - epidemiology
Nephrosclerosis - genetics
Nephrosclerosis - physiopathology
Phenotype
Polycystic Kidney Diseases - genetics
Polycystic Kidney Diseases - physiopathology
Prevalence
renal failure
United States - epidemiology
White People - genetics
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Summary:Background. Multiple studies suggest that hypertension‐induced end‐stage renal disease (ESRD) is heritable. Identification of nephropathy susceptibility genes absolutely requires accurate phenotyping, but the clinical hypertensive nephrosclerosis (HN) phenotype is poorly characterized. We hypothesized that many patients with HN as the indicated cause of ESRD on the Health Care Financing Administration (HCFA) 2728 form, fail to satisfy stringent HN phenotyping criteria. Methods. Since renal biopsy documentation of HN is uncommon, clinical parameters for HN phenotype were applied: family history of hypertension, left ventricular hypertrophy, proteinuria
ISSN:0931-0509
1460-2385
DOI:10.1093/ndt/15.11.1801