Effect of hypovolemic shock in anastomose of small intestine of rats

Study the effect of hypovolemic shock on small intestinal anastomose in adult rats. Ninety male rats were randomly divided into five groups: standard, hypovolemic shock, anastomose alone, hypovolemic shock + anastomose and hypovolemic shock + anastomose + blood reinfusion. Hypovolemic shock was achi...

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Bibliographic Details
Published in:Arquivos de gastroenterologia 2001-04, Vol.38 (2), p.116-124
Main Authors: Brito, M V, Koh, I H, Lamarão, L G, Damous, S H
Format: Article
Language:Portuguese
Subjects:
Anastomosis, Surgical
Animals
Intestinal Mucosa - pathology
Intestine, Small - pathology
Intestine, Small - surgery
Male
Rats
Rats, Wistar
Risk Factors
Shock - complications
Shock - pathology
Time Factors
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Summary:Study the effect of hypovolemic shock on small intestinal anastomose in adult rats. Ninety male rats were randomly divided into five groups: standard, hypovolemic shock, anastomose alone, hypovolemic shock + anastomose and hypovolemic shock + anastomose + blood reinfusion. Hypovolemic shock was achieved by bleeding 30% of the blood volume of the animal. A single layer extramucosal intestinal anastomose was performed. Following intestinal anastomose, the blood volume was restored in group shock, anastomose and blood reinfusion, using heparinized autologous. In the experimental model used, hypovolemic shock provoked histological lesions to the mucosa and increased colagen fiber deposition into the submucosa in the region of intestinal anastomose which were progressive with post-operative period. In addition, when the hypovolemic shock group were pressure tested there was a tendency towards a weakening of the intestinal wall at day 7 which became more evident at day 21 as compared to the control groups.
ISSN:0004-2803