Estrous cycle influences the response of female rats in the elevated plus-maze test

The aim of this study was to examine the state of anxiety and the 17β-estradiol and progesterone levels in rats tested in the elevated plus-maze during the four phases of the estrous cycle. Male rats, female rats during each of the four phases of the estrous cycle, ovariectomized rats, and diestrus...

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Bibliographic Details
Published in:Physiology & behavior 2001-11, Vol.74 (4), p.435-440
Main Authors: Marcondes, Fernanda Klein, Miguel, Katia Jacqueline, Melo, Liana Lins, Spadari-Bratfisch, Regina Célia
Format: Article
Language:English
Subjects:
Animals
Anxiety
Arousal - physiology
Biological and medical sciences
Elevated plus-maze test
Estradiol
Estradiol - blood
Estrous cycle
Estrus - physiology
Female
Maze Learning - physiology
Progesterone
Progesterone - blood
Rats
Rats, Wistar
Sex Characteristics
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Summary:The aim of this study was to examine the state of anxiety and the 17β-estradiol and progesterone levels in rats tested in the elevated plus-maze during the four phases of the estrous cycle. Male rats, female rats during each of the four phases of the estrous cycle, ovariectomized rats, and diestrus female rats treated with estradiol were tested in the elevated plus-maze between 8:00 and 10:00 a.m. Blood was collected from all rats for the determination of 17β-estradiol and progesterone levels. Female rats in the proestrus group spent more time in the open arms than diestrus rats ( P
ISSN:0031-9384
1873-507X
DOI:10.1016/S0031-9384(01)00593-5