Heme oxygenase1 (HSP-32) is induced in myelin-phagocytosing Schwann cells of injured sciatic nerves in the rat

Schwann cells participate in myelin phagocytosis in the early stage of Wallerian degeneration, prior to the recruitment of macrophages. This is the first report that Schwann cells induce heme oxygenase‐1 (HO‐1), a 32‐kDa heat shock protein, only when they have transformed into myelin‐phagocytosing c...

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Bibliographic Details
Published in:The European journal of neuroscience 2000-11, Vol.12 (11), p.4147-4152
Main Authors: Hirata, Kazuho, He, Jian-wen, Kuraoka, Akio, Omata, Yoshiaki, Hirata, Mizuki, Islam, A. T. M. Shariful, Noguchi, Masato, Kawabuchi, Masaru
Format: Article
Language:English
Subjects:
Animals
Antibodies
Enzyme Induction
Experiments
Heat shock proteins
Heme Oxygenase (Decyclizing) - biosynthesis
Heme Oxygenase-1
HO-1
immunohistochemistry
Labeling
Lasers
Male
myelin phagocytosis
Myelin Sheath - physiology
Nerve Crush
Nervous system
Rats
Rats, Wistar
Schwann cells
Schwann Cells - enzymology
Schwann Cells - physiology
Sciatic Nerve - enzymology
Sciatic Nerve - injuries
Sciatic Nerve - physiology
Wallerian Degeneration
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Summary:Schwann cells participate in myelin phagocytosis in the early stage of Wallerian degeneration, prior to the recruitment of macrophages. This is the first report that Schwann cells induce heme oxygenase‐1 (HO‐1), a 32‐kDa heat shock protein, only when they have transformed into myelin‐phagocytosing cells from myelinating cells (days 2–3) immediately after crush injury of rat sciatic nerves. Double immunofluorescent labelling for HO‐1 and transferrin receptors revealed that HO‐1‐immunoreactive Schwann cells also expressed transferrin receptors suggesting activation of iron metabolism. The transient induction of HO‐1 in Schwann cells may contribute to the adaptive function in an altered environment when the cells have lost contact with axons, and may play a crucial role in the ensuing regeneration.
ISSN:0953-816X
1460-9568
DOI:10.1046/j.1460-9568.2000.00307.x