Hepatic Progenitors and Strategies for Liver Cell Therapies

: Liver cell therapies, including liver cell transplantation and bioartificial livers, are being developed as alternatives to whole liver transplantation for some patients with severe liver dysfunction. Hepatic progenitors are proposed as ideal cells for use in these liver cell therapies given their...

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Bibliographic Details
Published in:Annals of the New York Academy of Sciences 2001-11, Vol.944 (1), p.398-419
Main Authors: SUSICK, R., MOSS, N., KUBOTA, H., LECLUYSE, E., HAMILTON, G., LUNTZ, T., LUDLOW, J., FAIR, J., GERBER, D., BERGSTRAND, K., WHITE, J., BRUCE, A., DRURY, O., GUPTA, S., REID, L. M.
Format: Article
Language:English
Subjects:
Animals
Cell Lineage
Cryopreservation
Hematopoietic Stem Cell Transplantation
hepatic progenitors
Hepatocytes - cytology
Hepatocytes - transplantation
Humans
liver
liver cell therapies
Liver Regeneration
liver transplantation
Rodentia
stem cells
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Summary:: Liver cell therapies, including liver cell transplantation and bioartificial livers, are being developed as alternatives to whole liver transplantation for some patients with severe liver dysfunction. Hepatic progenitors are proposed as ideal cells for use in these liver cell therapies given their ability to expand extensively, differentiate into all mature liver cells, have minimal immunogenicity, be cryopreservable, and reconstitute liver tissue when transplanted. We summarize our ongoing efforts to develop clinical programs of hepatic progenitor cell therapies with a focus on hepatic stem cell biology and strategies that have emerged in analyzing that biology.
ISSN:0077-8923
1749-6632
DOI:10.1111/j.1749-6632.2001.tb03851.x