Effects of 2-week ingestion of (−)-hydroxycitrate and (−)-hydroxycitrate combined with medium-chain triglycerides on satiety and food intake

• Published in: Physiology & behavior 2001-11, Vol.74 (4), p.543-549
• Main Authors: Kovacs, E.M.R., Westerterp-Plantenga, M.S., de Vries, M., Brouns, F., Saris, W.H.M.
• Format: Article
• Language: English
• Subjects: (−)-Hydroxycitrate; Adult; Appetite; Biological and medical sciences; Body weight loss; Citrates - administration & dosage; Cross-Over Studies; Double-Blind Method; Drug Therapy, Combination; Eating - drug effects; Energy intake; Energy Intake - drug effects; Female; Humans; hydrocitrate; Male; Medium-chain triglycerides; Middle Aged; Obesity - drug therapy; Satiety; Satiety Response - drug effects; Triglycerides - administration & dosage; Weight Loss - drug effects
• ISSN: 0031-9384; 1873-507X
• DOI: 10.1016/S0031-9384(01)00594-7

The aim of this study was to assess the effects of 2 weeks of supplementation with (−)-hydroxycitrate (HCA) and HCA combined with medium-chain triglycerides (MCT) on satiety and energy intake. The experimental design consisted of three intervention periods of 2 weeks separated by washout periods of 2 or 6 weeks in a double-blind, placebo-controlled, randomized, and crossover design. Seven male and 14 female normal to moderately obese subjects (mean±S.D.; age, 43±10 years; body mass index, 27.6±2.0 kg/m 2) participated in this study. Subjects consumed three self-selected meals and four isoenergetic snacks daily with either no supplementation (PLA), with 500 mg HCA (HCA), or 500 mg HCA and 3 g MCT (HCA+MCT). Each intervention period ended with a test day, consisting of a standardized breakfast and ad libitum a lunch and a dinner. There was a significant body weight (BW) loss during the 2 weeks of intervention (PLA, −0.5±0.3 kg, P