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Effects of 2-week ingestion of (−)-hydroxycitrate and (−)-hydroxycitrate combined with medium-chain triglycerides on satiety and food intake
The aim of this study was to assess the effects of 2 weeks of supplementation with (−)-hydroxycitrate (HCA) and HCA combined with medium-chain triglycerides (MCT) on satiety and energy intake. The experimental design consisted of three intervention periods of 2 weeks separated by washout periods of...
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| Published in: | Physiology & behavior 2001-11, Vol.74 (4), p.543-549 |
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| container_start_page | 543 |
| container_title | Physiology & behavior |
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| creator | Kovacs, E.M.R. Westerterp-Plantenga, M.S. de Vries, M. Brouns, F. Saris, W.H.M. |
| description | The aim of this study was to assess the effects of 2 weeks of supplementation with (−)-hydroxycitrate (HCA) and HCA combined with medium-chain triglycerides (MCT) on satiety and energy intake. The experimental design consisted of three intervention periods of 2 weeks separated by washout periods of 2 or 6 weeks in a double-blind, placebo-controlled, randomized, and crossover design. Seven male and 14 female normal to moderately obese subjects (mean±S.D.; age, 43±10 years; body mass index, 27.6±2.0 kg/m
2) participated in this study. Subjects consumed three self-selected meals and four isoenergetic snacks daily with either no supplementation (PLA), with 500 mg HCA (HCA), or 500 mg HCA and 3 g MCT (HCA+MCT). Each intervention period ended with a test day, consisting of a standardized breakfast and ad libitum a lunch and a dinner. There was a significant body weight (BW) loss during the 2 weeks of intervention (PLA, −0.5±0.3 kg,
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| doi_str_mv | 10.1016/S0031-9384(01)00594-7 |
| format | article |
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2) participated in this study. Subjects consumed three self-selected meals and four isoenergetic snacks daily with either no supplementation (PLA), with 500 mg HCA (HCA), or 500 mg HCA and 3 g MCT (HCA+MCT). Each intervention period ended with a test day, consisting of a standardized breakfast and ad libitum a lunch and a dinner. There was a significant body weight (BW) loss during the 2 weeks of intervention (PLA, −0.5±0.3 kg,
P<.05; HCA, −0.4±0.2 kg,
P<.05; HCA+MCT, −0.7±0.2 kg,
P<.01), but this reduction was not different between treatments. Twenty-four-hour energy intake (PLA, 8.1±0.3 MJ; HCA, 8.3±0.3 MJ; HCA+MCT, 8.4±0.3 MJ) and the area under the curve of the appetite-related parameters during the test day were similar for all treatments. Two weeks of supplementation with HCA and HCA combined with MCT did not result in increased satiety or decreased energy intake compared to placebo in subjects losing BW.</description><identifier>ISSN: 0031-9384</identifier><identifier>EISSN: 1873-507X</identifier><identifier>DOI: 10.1016/S0031-9384(01)00594-7</identifier><identifier>PMID: 11790414</identifier><language>eng</language><publisher>Cambridge: Elsevier Inc</publisher><subject>(−)-Hydroxycitrate ; Adult ; Appetite ; Biological and medical sciences ; Body weight loss ; Citrates - administration & dosage ; Cross-Over Studies ; Double-Blind Method ; Drug Therapy, Combination ; Eating - drug effects ; Energy intake ; Energy Intake - drug effects ; Female ; Humans ; hydrocitrate ; Male ; Medium-chain triglycerides ; Middle Aged ; Obesity - drug therapy ; Satiety ; Satiety Response - drug effects ; Triglycerides - administration & dosage ; Weight Loss - drug effects</subject><ispartof>Physiology & behavior, 2001-11, Vol.74 (4), p.543-549</ispartof><rights>2001 Elsevier Science Inc.</rights><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c469t-ee84b5835d56cbfd9c51e8a08543cddb543ad70cc1048054a6b863a7b48f43033</citedby><cites>FETCH-LOGICAL-c469t-ee84b5835d56cbfd9c51e8a08543cddb543ad70cc1048054a6b863a7b48f43033</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13418275$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11790414$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kovacs, E.M.R.</creatorcontrib><creatorcontrib>Westerterp-Plantenga, M.S.</creatorcontrib><creatorcontrib>de Vries, M.</creatorcontrib><creatorcontrib>Brouns, F.</creatorcontrib><creatorcontrib>Saris, W.H.M.</creatorcontrib><title>Effects of 2-week ingestion of (−)-hydroxycitrate and (−)-hydroxycitrate combined with medium-chain triglycerides on satiety and food intake</title><title>Physiology & behavior</title><addtitle>Physiol Behav</addtitle><description>The aim of this study was to assess the effects of 2 weeks of supplementation with (−)-hydroxycitrate (HCA) and HCA combined with medium-chain triglycerides (MCT) on satiety and energy intake. The experimental design consisted of three intervention periods of 2 weeks separated by washout periods of 2 or 6 weeks in a double-blind, placebo-controlled, randomized, and crossover design. Seven male and 14 female normal to moderately obese subjects (mean±S.D.; age, 43±10 years; body mass index, 27.6±2.0 kg/m
2) participated in this study. Subjects consumed three self-selected meals and four isoenergetic snacks daily with either no supplementation (PLA), with 500 mg HCA (HCA), or 500 mg HCA and 3 g MCT (HCA+MCT). Each intervention period ended with a test day, consisting of a standardized breakfast and ad libitum a lunch and a dinner. There was a significant body weight (BW) loss during the 2 weeks of intervention (PLA, −0.5±0.3 kg,
P<.05; HCA, −0.4±0.2 kg,
P<.05; HCA+MCT, −0.7±0.2 kg,
P<.01), but this reduction was not different between treatments. Twenty-four-hour energy intake (PLA, 8.1±0.3 MJ; HCA, 8.3±0.3 MJ; HCA+MCT, 8.4±0.3 MJ) and the area under the curve of the appetite-related parameters during the test day were similar for all treatments. Two weeks of supplementation with HCA and HCA combined with MCT did not result in increased satiety or decreased energy intake compared to placebo in subjects losing BW.</description><subject>(−)-Hydroxycitrate</subject><subject>Adult</subject><subject>Appetite</subject><subject>Biological and medical sciences</subject><subject>Body weight loss</subject><subject>Citrates - administration & dosage</subject><subject>Cross-Over Studies</subject><subject>Double-Blind Method</subject><subject>Drug Therapy, Combination</subject><subject>Eating - drug effects</subject><subject>Energy intake</subject><subject>Energy Intake - drug effects</subject><subject>Female</subject><subject>Humans</subject><subject>hydrocitrate</subject><subject>Male</subject><subject>Medium-chain triglycerides</subject><subject>Middle Aged</subject><subject>Obesity - drug therapy</subject><subject>Satiety</subject><subject>Satiety Response - drug effects</subject><subject>Triglycerides - administration & dosage</subject><subject>Weight Loss - drug effects</subject><issn>0031-9384</issn><issn>1873-507X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><recordid>eNqFkc1uFSEUx4nR2NvqI2hmo2kXKFxgYFaNaepH0sSFmrgjDBx6sTNDBa513qBL4yP6JHI_YjcmZXMS-B3-cH4IPaPkFSW0ff2JEEZxxxQ_JvSEENFxLB-gBVWSYUHk14do8Q85QIc5fyN1Mc4eowNKZUc45Qv069x7sCU30TdLfANw1YTpEnIJcdrsHf-5_X2CV7NL8edsQ0mmQGMm9_8DG8c-TOCam1BWzQgurEdsVyZMTUnhcpgtpOCgpk1NNiVAmbeX-RhdzS3mCp6gR94MGZ7u6xH68vb889l7fPHx3YezNxfY8rYrGEDxXigmnGht711nBQVliBKcWef6WoyTxFpKuCKCm7ZXLTOy58pzRhg7Qi93916n-H1dP6zHkC0Mg5kgrrOWS044X7b3glQxWUN4BcUOtCnmnMDr6xRGk2ZNid4401tneiNEE6q3zrSsfc_3Aeu-juyuay-pAi_2gMnWDD6ZyYZ8xzFO1VKKyp3uOKhz-xEg6WwDTLZqSNWxdjHc85S_JEm2dg</recordid><startdate>20011101</startdate><enddate>20011101</enddate><creator>Kovacs, E.M.R.</creator><creator>Westerterp-Plantenga, M.S.</creator><creator>de Vries, M.</creator><creator>Brouns, F.</creator><creator>Saris, W.H.M.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7X8</scope></search><sort><creationdate>20011101</creationdate><title>Effects of 2-week ingestion of (−)-hydroxycitrate and (−)-hydroxycitrate combined with medium-chain triglycerides on satiety and food intake</title><author>Kovacs, E.M.R. ; Westerterp-Plantenga, M.S. ; de Vries, M. ; Brouns, F. ; Saris, W.H.M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c469t-ee84b5835d56cbfd9c51e8a08543cddb543ad70cc1048054a6b863a7b48f43033</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>(−)-Hydroxycitrate</topic><topic>Adult</topic><topic>Appetite</topic><topic>Biological and medical sciences</topic><topic>Body weight loss</topic><topic>Citrates - administration & dosage</topic><topic>Cross-Over Studies</topic><topic>Double-Blind Method</topic><topic>Drug Therapy, Combination</topic><topic>Eating - drug effects</topic><topic>Energy intake</topic><topic>Energy Intake - drug effects</topic><topic>Female</topic><topic>Humans</topic><topic>hydrocitrate</topic><topic>Male</topic><topic>Medium-chain triglycerides</topic><topic>Middle Aged</topic><topic>Obesity - drug therapy</topic><topic>Satiety</topic><topic>Satiety Response - drug effects</topic><topic>Triglycerides - administration & dosage</topic><topic>Weight Loss - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kovacs, E.M.R.</creatorcontrib><creatorcontrib>Westerterp-Plantenga, M.S.</creatorcontrib><creatorcontrib>de Vries, M.</creatorcontrib><creatorcontrib>Brouns, F.</creatorcontrib><creatorcontrib>Saris, W.H.M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Physiology & behavior</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kovacs, E.M.R.</au><au>Westerterp-Plantenga, M.S.</au><au>de Vries, M.</au><au>Brouns, F.</au><au>Saris, W.H.M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of 2-week ingestion of (−)-hydroxycitrate and (−)-hydroxycitrate combined with medium-chain triglycerides on satiety and food intake</atitle><jtitle>Physiology & behavior</jtitle><addtitle>Physiol Behav</addtitle><date>2001-11-01</date><risdate>2001</risdate><volume>74</volume><issue>4</issue><spage>543</spage><epage>549</epage><pages>543-549</pages><issn>0031-9384</issn><eissn>1873-507X</eissn><abstract>The aim of this study was to assess the effects of 2 weeks of supplementation with (−)-hydroxycitrate (HCA) and HCA combined with medium-chain triglycerides (MCT) on satiety and energy intake. The experimental design consisted of three intervention periods of 2 weeks separated by washout periods of 2 or 6 weeks in a double-blind, placebo-controlled, randomized, and crossover design. Seven male and 14 female normal to moderately obese subjects (mean±S.D.; age, 43±10 years; body mass index, 27.6±2.0 kg/m
2) participated in this study. Subjects consumed three self-selected meals and four isoenergetic snacks daily with either no supplementation (PLA), with 500 mg HCA (HCA), or 500 mg HCA and 3 g MCT (HCA+MCT). Each intervention period ended with a test day, consisting of a standardized breakfast and ad libitum a lunch and a dinner. There was a significant body weight (BW) loss during the 2 weeks of intervention (PLA, −0.5±0.3 kg,
P<.05; HCA, −0.4±0.2 kg,
P<.05; HCA+MCT, −0.7±0.2 kg,
P<.01), but this reduction was not different between treatments. Twenty-four-hour energy intake (PLA, 8.1±0.3 MJ; HCA, 8.3±0.3 MJ; HCA+MCT, 8.4±0.3 MJ) and the area under the curve of the appetite-related parameters during the test day were similar for all treatments. Two weeks of supplementation with HCA and HCA combined with MCT did not result in increased satiety or decreased energy intake compared to placebo in subjects losing BW.</abstract><cop>Cambridge</cop><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>11790414</pmid><doi>10.1016/S0031-9384(01)00594-7</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0031-9384 |
| ispartof | Physiology & behavior, 2001-11, Vol.74 (4), p.543-549 |
| issn | 0031-9384 1873-507X |
| language | eng |
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| source | ScienceDirect Freedom Collection 2022-2024 |
| subjects | (−)-Hydroxycitrate Adult Appetite Biological and medical sciences Body weight loss Citrates - administration & dosage Cross-Over Studies Double-Blind Method Drug Therapy, Combination Eating - drug effects Energy intake Energy Intake - drug effects Female Humans hydrocitrate Male Medium-chain triglycerides Middle Aged Obesity - drug therapy Satiety Satiety Response - drug effects Triglycerides - administration & dosage Weight Loss - drug effects |
| title | Effects of 2-week ingestion of (−)-hydroxycitrate and (−)-hydroxycitrate combined with medium-chain triglycerides on satiety and food intake |
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