Pharmacokinetic and Pharmacodynamic Comparison of Two Calcium Supplements in Postmenopausal Women

This randomized crossover study compared the single‐dose bioavailability and effects on parathyroid function of two commercially formulated calcium supplements containing 500 mg of elemental calcium. Twenty‐five postmenopausal women underwent three phases of study wherein they each took a single dos...

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Bibliographic Details
Published in:Journal of clinical pharmacology 2000-11, Vol.40 (11), p.1237-1244
Main Authors: Heller, Howard J., Greer, Laura G., Haynes, Sharon D., Poindexter, John R., Pak, Charles Y. C.
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Biological Availability
Calcium Carbonate - administration & dosage
Calcium Carbonate - pharmacokinetics
Calcium Carbonate - pharmacology
Calcium Citrate - administration & dosage
Calcium Citrate - pharmacokinetics
Calcium Citrate - pharmacology
Cross-Over Studies
Female
Humans
Medical sciences
Middle Aged
Miscellaneous
Parathyroid Hormone - blood
Pharmacology. Drug treatments
Postmenopause - metabolism
Sodium, Dietary - administration & dosage
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Summary:This randomized crossover study compared the single‐dose bioavailability and effects on parathyroid function of two commercially formulated calcium supplements containing 500 mg of elemental calcium. Twenty‐five postmenopausal women underwent three phases of study wherein they each took a single dose of calcium citrate with a standard breakfast (as Citracal® 250 mg + D), calcium carbonate (as Os‐Cal ®500 mg + D), or placebo at 8 a.m. Blood samples were drawn at baseline and hourly for 4 or 6 hours after each dose. Fasting and postload urine samples were also collected. Compared with calcium carbonate, calcium citrate provided a 46% greater peak‐basal variation and 94% higher change in area under the curve for serum calcium and a 41% greater increment in urinary calcium. Moreover, the decrement in serum parathyroid hormone concentration from baseline was greater after calcium citrate. In conclusion, calcium citrate is more bioavailable than calcium carbonate when given with a meal.
ISSN:0091-2700
1552-4604
DOI:10.1177/009127000004001108