Neurotrophin-3 and neurotrophin receptor immunoreactivity in peptidergic enteric neurons

In the rat small intestine, neurotrophin-3 immunoreactivity was identified in ganglion cells and in processes mostly innervating the mucosa and occasionally the muscle layer and vasculature. The vast majority of neurotrophin-3 immunoreactive neurons contained vasoactive intestinal polypeptide (VIP),...

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Bibliographic Details
Published in:Peptides (New York, N.Y. : 1980) N.Y. : 1980), 2000-09, Vol.21 (9), p.1421-1426
Main Authors: De Giorgio, Roberto, Arakawa, Janice, Wetmore, Cynthia J., Sternini, Catia
Format: Article
Language:English
Subjects:
Animals
Enteric nervous system
Enteric Nervous System - chemistry
Female
Ganglia - chemistry
Immunohistochemistry
Intestine, Small - chemistry
Intestine, Small - innervation
Male
Myenteric Plexus - chemistry
Nerve growth factor
Neurons - chemistry
Neurotrophin 3 - isolation & purification
Neurotrophins
Peptide-containing neurons
Rats
Rats, Sprague-Dawley
Receptors, Nerve Growth Factor - isolation & purification
Synaptic Transmission
Tyrosine kinase receptor
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Summary:In the rat small intestine, neurotrophin-3 immunoreactivity was identified in ganglion cells and in processes mostly innervating the mucosa and occasionally the muscle layer and vasculature. The vast majority of neurotrophin-3 immunoreactive neurons contained vasoactive intestinal polypeptide (VIP), but not substance P or related tachykinin (SP/TK). Neurotrophin receptors visualized by pan- trk immunoreactivity were found in numerous ganglion cells of both plexuses and in nerve processes in the intestinal wall. Pan- trk submucosal neurons contained VIP (36%) or SP/TK-IR (47%). Pan- trk myenteric neurons contained VIP-IR (57%) or SP/TK (27%). Our data suggest that neurotrophin-3 and neurotrophin receptors may be involved in the maintenance of enteric neuronal circuits, transmission and phenotypic expression.
ISSN:0196-9781
1873-5169
DOI:10.1016/S0196-9781(00)00286-2