Malignant Lymphoma in Nasal Cavity and Paranasal Sinuses of a Dog

• Published in: Journal of veterinary medicine. Series A 2000-10, Vol.47 (8), p.457-462
• Main Authors: Kaldrymidou, E., Papaioannou, N., Poutahidis, TH, Karayannopoulou, M., Gruys, E., Toliou, TH, Tsangaris, TH
• Format: Article
• Language: English
• Subjects: Animals; Antibodies, Monoclonal; Dog Diseases - pathology; Dogs; Fatal Outcome; Immunohistochemistry; Lymphoma, Large B-Cell, Diffuse - pathology; Lymphoma, Large B-Cell, Diffuse - veterinary; Male; Microscopy, Electron - veterinary; Nasal Cavity - diagnostic imaging; Nasal Cavity - pathology; Nose Neoplasms - pathology; Nose Neoplasms - veterinary; Paranasal Sinus Neoplasms - pathology; Paranasal Sinus Neoplasms - veterinary; Paranasal Sinuses - diagnostic imaging; Paranasal Sinuses - pathology; Radiography
• ISSN: 0931-184X; 1439-0442
• DOI: 10.1046/j.1439-0442.2000.00293.x

Summary A case of a canine large cell type T‐cell lymphoma, with features of high‐grade malignancy is described. The tumour was found confined in the nasal cavity and the paranasal sinuses of a crossbred German Shepherd dog. Histological examination revealed the features of a highly malignant large cell lymphoma. Ultrastructurally, the lymphoid tumour cells bore cytoplasmic protrusions that interdigitated tightly. From a panel of tumour markers used, the neoplastic cells were stained only for vimentin. Immunophenotyping of the tumour cells by means of CD3, CD79, κ‐light chains and λ‐light chains detection was undertaken. The tumour stained only for CD3 and was classified as T‐cell lymphoma.